Showing papers by "Michael P. Alexander published in 1980"
TL;DR: Clinicoanatomic correlations revealed no definite differences between aphasia after hemorrhage in putamen or in thalamus, and the range of language and behavioral disorders produced was described.
Abstract: The function of subcortical nuclear structures in language is uncertain, and language disorders after injury to these structures are described incompletely. We report 15 patients with left putaminal or thalamic hemorrhage, describe the range of language and behavioral disorders produced, and review the potential mechanisms of these disorders. Clinicoanatomic correlations revealed no definite differences between aphasia after hemorrhage in putamen or in thalamus.
181 citations
TL;DR: Two patients with transcortical motor aphasia had infarcts in the distribution of the left anterior cerebral artery confirmed by computerized tomography (CT), allowing ready diagnosis of the syndrome of infarction in this distribution.
Abstract: • Two patients with transcortical motor aphasia are described. Both had infarcts in the distribution of the left anterior cerebral artery confirmed by computerized tomography (CT). The distinctive language abnormality, unusual EEG pattern, and nuclide and CT scan abnormalities all allow ready diagnosis of the syndrome of infarction in this distribution. The mechanism of the language disturbance is reviewed and implications for treatment and prognosis are discussed.
102 citations
TL;DR: It is suggested that a holiday from L-DOPA therapy may extend the drug's usefulness in treating Parkinson disease, perhaps by resensitizing striatal dopamine receptors in patients receiving the drug for prolonged periods.
Abstract: We studied 9 patients with severe, chronic Parkinson disease and complications of long-term L-DOPA therapy. After a "holiday" of 3 to 21 days, excess dopamine effects improved in all patients, and the baseline parkinsonian picture emerged. After reinstitution of L-DOPA therapy, often at lower doses than had been used previously, parkinsonian signs improved. Complications of immobility were seen in two patients; one had deep vein thrombophlebitis, and the other became depressed. In treating the individual patient, the risks of immobility despite aggressive attempts to prevent complications should be weighed against the possible improvement of parkinsonism. These findings suggest that a holiday from L-DOPA therapy may extent the drug's usefulness in treating Parkinson disease, perhaps by resensitizing striatal dopamine receptors in patients receiving the drug for prolonged periods.
44 citations