M
Michael Reedijk
Researcher at Princess Margaret Cancer Centre
Publications - 31
Citations - 2414
Michael Reedijk is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Notch signaling pathway & Breast cancer. The author has an hindex of 16, co-authored 27 publications receiving 2081 citations. Previous affiliations of Michael Reedijk include Hospital for Sick Children & The Breast Cancer Research Foundation.
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Journal ArticleDOI
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.
Michael Reedijk,Silvia Odorcic,Lynn Chang,Hui Zhang,Naomi Miller,David R. McCready,Gina Lockwood,Sean E. Egan +7 more
TL;DR: The data identify novel prognostic markers for breast cancer, suggest a mechanism whereby Notch is activated in aggressive breast tumors, and suggest a signaling pathway activated in poor prognosis breast cancer which can be therapeutically targeted.
Journal ArticleDOI
Activation of Notch signaling in human colon adenocarcinoma
Michael Reedijk,Silvia Odorcic,Hui Zhang,Runjan Chetty,Carsten Tennert,Brendan C. Dickson,Gina Lockwood,Steven Gallinger,Sean E. Egan +8 more
TL;DR: In situ hybridization is used to analyze expression of Notch ligands, receptors and fringe genes, as well as the Notch target gene, HES1, in human colorectal cancer (CRC), to establish that JAG ligands and NOTCH1, aswell as Notch receptor activation are consistent features of human CRC and support the notion that many of these tumors may respond to anti-Notch therapeutic regimes.
Journal ArticleDOI
High-level JAG1 mRNA and protein predict poor outcome in breast cancer
Brendan C. Dickson,Anna Marie Mulligan,Hui Zhang,Gina Lockwood,Frances P O'Malley,Sean E. Egan,Michael Reedijk,Michael Reedijk,Michael Reedijk +8 more
TL;DR: The data show that the Allred score can be used to rapidly quantify JAG1 mRNA and protein levels in breast cancer to identify patients who have a significant survival disadvantage and who may benefit from therapies that target signaling through the Notch pathway.
Journal ArticleDOI
A Multicentered, Randomized, Controlled Trial Comparing Radioguided Seed Localization to Standard Wire Localization for Nonpalpable, Invasive and in situ Breast Carcinomas
Peter Lovrics,Peter Lovrics,Charles H. Goldsmith,Charles H. Goldsmith,Nicole Hodgson,Nicole Hodgson,David R. McCready,Gabriela Gohla,Colm Boylan,Sylvie D. Cornacchi,Michael Reedijk +10 more
TL;DR: In contrast to other trials positive margin and reoperation rates were similar for RSL and WL, and the technique was preferred by surgeons, making it an acceptable method for localization.
Journal ArticleDOI
JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
Michael Reedijk,Michael Reedijk,Michael Reedijk,Dushanthi Pinnaduwage,Brendan C. Dickson,Anna Marie Mulligan,Hui Zhang,Shelley B. Bull,Shelley B. Bull,Frances P. O'Malley,Frances P. O'Malley,Sean E. Egan,Sean E. Egan,Irene L. Andrulis,Irene L. Andrulis +14 more
TL;DR: JAG1 expression is associated with poor DFS in LNN breast cancer, and novel insights into signaling that may contribute to progression of early stage breast cancer are provided.