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Showing papers by "Michel Bouvier published in 2023"

Journal Article•DOI•
Enhanced Bystander BRET (ebBRET) Biosensors as Biophysical Tools to Map the Signaling Profile of Neuropsychiatric Drugs Targeting GPCRs.

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Supriya A Gaitonde, Michel Bouvier
Journal Article•DOI•
The ubiquitination status of the glucagon receptor determines signal bias

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Suneet Kaur, Badr Sokrat, Megan E. Capozzi, Kimberley El, Yushi Bai, David A. D'Alessio, Jonathan E. Campbell, Michel Bouvier, Sudha K. Shenoy 
01 Apr 2023-Journal of Biological Chemistry
TL;DR: In this article , a link between the ubiquitination status and signal transduction mechanism of the glucagon receptor (GCGR) was reported, where the GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.