M
Michel Noutsias
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 202
Citations - 7858
Michel Noutsias is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Cardiomyopathy & Dilated cardiomyopathy. The author has an hindex of 39, co-authored 194 publications receiving 6594 citations. Previous affiliations of Michel Noutsias include RK University & University of Tübingen.
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Journal ArticleDOI
High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction.
Uwe Kühl,Matthias Pauschinger,Michel Noutsias,Bettina Seeberg,Thomas Bock,Dirk Lassner,Wolfgang Poller,Reinhard Kandolf,Heinz-Peter Schultheiss +8 more
TL;DR: Viral genomes were frequently detected in EMBs of patients with systolic left ventricular dysfunction, suggesting that myocardial persistence of various viruses may play a role in the pathogenesis of DCM far more frequently than suspected so far.
Journal ArticleDOI
Viral Persistence in the Myocardium Is Associated With Progressive Cardiac Dysfunction
Uwe Kühl,Matthias Pauschinger,Bettina Seeberg,Dirk Lassner,Michel Noutsias,Wolfgang Poller,Heinz-Peter Schultheiss +6 more
TL;DR: In this first biopsy-based analysis of the course of viral heart disease, it is shown that EV, ADV, PVB19, and HHV6 persistence detected in the myocardium of patients with LV dysfunction was associated with a progressive impairment of LVEF, whereas spontaneous viral elimination wasassociated with a significant improvement in LV function.
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Interferon-β Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction
Uwe Kühl,Matthias Pauschinger,Peter L. Schwimmbeck,Bettina Seeberg,Conny Lober,Michel Noutsias,Wolfgang Poller,Heinz-Peter Schultheiss +7 more
TL;DR: A 6 months of IFN-&bgr; treatment was safe in patients with myocardial enteroviral or adenoviral persistence and LV dysfunction and resulted in elimination of viral genomes and improved LV function.
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Suspected chronic myocarditis at cardiac MR: diagnostic accuracy and association with immunohistologically detected inflammation and viral persistence.
Matthias Gutberlet,Birgit Spors,Tobias Thoma,Henriette Bertram,Timm Denecke,Roland Felix,Michel Noutsias,Heinz-Peter Schultheiss,Uwe Kühl +8 more
TL;DR: In patients clinically suspected of having CMC, increased gRE and ER indicating inflammation were common findings that could be confirmed at immunohistologic analysis, whereas LE had low sensitivity and accuracy.
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Immunohistological evidence for a chronic intramyocardial inflammatory process in dilated cardiomyopathy.
TL;DR: Nearly half the patients with DCM had increased T lymphocyte density and immune activation of endothelial and interstitial cells in their cardiac biopsies, indicating a chronic autoimmune process is still active within the myocardium in a significant percentage of patients withDCM.