M
Michelle D. Combs
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 6
Citations - 726
Michelle D. Combs is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Cathepsin K & RANKL. The author has an hindex of 6, co-authored 6 publications receiving 662 citations.
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Journal ArticleDOI
Heart Valve Development: Regulatory networks in development and disease
TL;DR: The cellular and molecular mechanisms underlying the early development of valve progenitors and establishment of normal valve structure and function are reviewed.
Journal ArticleDOI
Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart
TL;DR: A critical role for Pod1 is demonstrated in controlling mesenchymal progenitor cell differentiation into SM and fibroblast lineages during cardiac development.
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VEGF and RANKL Regulation of NFATc1 in Heart Valve Development
TL;DR: A novel mechanism for the transition from ECC growth to remodeling in which NFATc1 promotes a sequential pattern of gene expression via cooperation with ligand-specific cofactors such as MEK1-ERK1/2 or JNK1/ 2 is supported.
Journal ArticleDOI
Transcriptional Regulation of Heart Valve Progenitor Cells
TL;DR: Together, the precise timing and localized functions of specific transcription factors control cell proliferation, differentiation, elongation, and remodeling processes that are necessary for normal valve structure and function.
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NFATC1 promotes epicardium-derived cell invasion into myocardium.
TL;DR: A crucial role is demonstrated for the RANKL/NFATC1 signaling pathway in promoting invasion of EPDCs into the myocardium by induction of extracellular matrix-degrading enzyme gene expression.