M
Mineharu Hiiragi
Researcher at Tohoku University
Publications - 161
Citations - 573
Mineharu Hiiragi is an academic researcher from Tohoku University. The author has contributed to research in topics: Carboxylic acid & Isoquinoline. The author has an hindex of 11, co-authored 161 publications receiving 570 citations.
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Journal ArticleDOI
Studies on the Synthesis of Chemotherpeutics. Part XI. Synthesis and Antibacterial Activities of Phosphonopeptides
Tetsuji Kametani,Kazuo Kigasawa,Mineharu Hiiragi,Kikuo Wakisaka,Seiji Haga,Hideo Sugi,Keizo Tanigawa,Yukio Suzuki,Kazunaga Fukawa,Osamu Irino,Osamu Saita,Shigeru Yamabe +11 more
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Studies on the syntheses of heterocyclic compounds. 845. Studies on the synthesis of chemotherapeutics. 10. Synthesis and antitumor activity of N-acyl- and N-(alkoxycarbonyl)-5-fluorouracil derivatives
Tetsuji Kametani,Kazuo Kigasawa,Mineharu Hiiragi,Kikuo Wakisaka,Seiji Haga,Y Nagamatsu,Hideo Sugi,Kazunaga Fukawa,Osamu Irino,T Yamamoto,N Nishimura,A Taguchi,Okada Taiji,M Nakayama +13 more
TL;DR: N1-acetyl-N3-o-toluyl-5-fluorouracil was found to be most promising among them, and 12 to retain higher activity toward various tumors, with lower toxicity and good blood level, than either 1 or FT-207, even for oral administration.
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Phenolic cyclisation. Part I. Novel synthesis of 1-substituted isoquinoline and spiro[cycloalkane-1,1′-isoquinoline] derivatives and its application to the total synthesis of isoquinoline alkaloids
Tetsuji Kametani,K. Fukumoto,H. Agui,H. Yagi,K. Kigasawa,H. Sugahara,Mineharu Hiiragi,Tetsutaro Hayasaka,Haruhide Ishimaru +8 more
TL;DR: In this article, condensation of 3-hydroxyphenethylamine with carbonyl compounds led to the total synthesis of (±)-coreximine and spiro[cycloalkane-1,1′-isoquinoline] derivatives.
Journal ArticleDOI
Studies on the syntheses of heterocyclic compounds. Part CCCLXXXVI. Alternative total syntheses of galanthamine and N-benzylgalanthamine iodide
Tetsuji Kametani,C. Seino,K. Yamaki,Shiroshi Shibuya,K. Fukumoto,K. Kigasawa,Fumio Satoh,Mineharu Hiiragi,Tetsutaro Hayasaka +8 more
TL;DR: In this paper, N-benzyl-galanthamine iodide (VIa) was synthesized by phenolic oxidative reactions of the corresponding amides (IIIf and e) and showed analgesic activity comparable to that of morphine.