M
Minsheng Wang
Researcher at Emory University
Publications - 7
Citations - 1767
Minsheng Wang is an academic researcher from Emory University. The author has contributed to research in topics: Wallerian degeneration & Neurite. The author has an hindex of 7, co-authored 7 publications receiving 1627 citations.
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Journal ArticleDOI
Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man.
Lindsey R. Fischer,Deborah G. Culver,Philip Tennant,Albert A. Davis,Minsheng Wang,Amilcar A. Castellano-Sanchez,Jaffar M. Khan,Meraida Polak,Jonathan D. Glass +8 more
TL;DR: It is concluded that in this widely studied animal model of human ALS, and in this single human case, motor neuron pathology begins at the distal axon and proceeds in a "dying back" pattern.
Journal ArticleDOI
NAD + and axon degeneration revisited: Nmnat1 cannot substitute for Wld S to delay Wallerian degeneration
Laura Conforti,G Fang,Bogdan Beirowski,Minsheng Wang,Leonardo Sorci,Seneshaw Asress,Robert Adalbert,A Silva,Katherine Bridge,X P Huang,Giulio Magni,Jonathan D. Glass,Michael P. Coleman +12 more
TL;DR: Nmnat1 is significantly weaker than WldS at protecting axons against traumatic or toxic injury in vitro, and has no detectable effect in vivo.
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The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse.
Lindsey R. Fischer,Deborah G. Culver,Albert A. Davis,Philip Tennant,Minsheng Wang,Michael P. Coleman,Seneshaw Asress,Robert Adalbert,Guillermo M. Alexander,Jonathan D. Glass +9 more
TL;DR: It is reported that SOD1G93A mice show significant degeneration of sensory axons during the course of disease, supporting previous data from humans demonstrating that ALS is not purely a motor disorder.
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Pathogenesis of axonal degeneration: parallels between Wallerian degeneration and vincristine neuropathy.
TL;DR: It is suggested that common mechanisms involving calcium and calpains are involved in both axotomy-induced and vincristine-induced axonal degeneration, and calpain inhibition may provide a strategy for preventing axonic degeneration and preserving neurologic function in a variety of PNS and CNS disorders.
Journal ArticleDOI
The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine Neuropathy
TL;DR: Common pathophysiologic mechanisms between axotomy-induced Wallerian degeneration and toxic neuropathy are suggested and are relevant to the pathophysiology of axonal degeneration seen in a wide spectrum of neurological diseases ranging from stroke and head trauma to spinal cord injury and peripheral neuropathy.