Miori Inoue

TL;DR: Findings indicate that IAP family proteins might play a role in worsening the prognosis of MM patients in association with chemotherapy‐induced overexpression of MDR1 or LRP, and changes in the expression of IAPs induced by chemotherapy did not correlate with their prognosis.

TL;DR: TNF- alpha-induced apoptosis may play a role in ineffective hematopoiesis in "early stage MDS" bone marrow, although the regulatory mechanisms for TNF-alpha-induced signaling would be complicated and not be simply explained only by these pathways.

TL;DR: Comparing the expression of the inhibitor of apoptosis protein (IAP) gene family proteins in bone marrow samples from control, MDS, OL transformed from MDS (MDS --> OL), and de novo acute myelogenous leukemia (AML) subjects by the quantitative real-time RT-PCR method and an immunohistochemical approach indicates that these IAPs could be associated with the early events in the development of OL.

TL;DR: Observations indicate a differential regulatory mechanism for the expression of IAP family proteins in ALL and CLL cells, although the functions of I AP families and the mechanisms of nuclear/cytoplasmic transport of survivin should be clarified in future studies.

TL;DR: Findings suggest that higher expression of various IAPs is associated with the chemotherapy‐resistant nature of this specific type of leukemia.