M
Miriam Breunig
Researcher at University of Regensburg
Publications - 54
Citations - 3824
Miriam Breunig is an academic researcher from University of Regensburg. The author has contributed to research in topics: Gene delivery & Nanoparticle. The author has an hindex of 22, co-authored 51 publications receiving 3507 citations.
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Polyethylenimine-based non-viral gene delivery systems.
TL;DR: Insight is given into strategies developed for PEI-based non-viral vectors to overcome intracellular obstacles, including the improvement of methods for polyplex preparation and the incorporation of endosomolytic agents or nuclear localization signals.
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Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery
TL;DR: The manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach is demonstrated and the cellular delivery and siRNA activity as functions of surface properties are reported on.
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Breaking up the correlation between efficacy and toxicity for nonviral gene delivery
TL;DR: Red reductive degradation is a highly promising tool for the design of new transfection materials because it produces mainly nontoxic fragments and substantially lower toxicities.
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Delivery of Nucleic Acids via Disulfide‐Based Carrier Systems
TL;DR: In this review, emphasis is placed on the biological rationale for the synthesis of redox sensitive, disulfide‐based carrier systems, as well as the extra‐ and intracellular processing of macromolecules containing disulfides.
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Polymers and nanoparticles: Intelligent tools for intracellular targeting?
TL;DR: This review describes how the drugs can be directed to specific subcellular organelles and focus especially on synthetic polymers and nanoparticles as their carriers and the progress that has been accomplished in recent years in the field of designing the carriers for efficient delivery into these target structures.