M
Mitra C. Singhal
Researcher at Bristol-Myers Squibb
Publications - 4
Citations - 475
Mitra C. Singhal is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: CTL* & Virus. The author has an hindex of 4, co-authored 4 publications receiving 471 citations.
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Journal ArticleDOI
Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees.
Shiu Lok Hu,P N Fultz,P N Fultz,Harold M. McClure,Jorg W. Eichberg,Thomas Elaine K,Joyce M. Zarling,Mitra C. Singhal,Steven G. Kosowski,R. Brent Swenson,Daniel C. Anderson,George J. Todaro +11 more
TL;DR: Results of an HIV vaccine trial in which nine chimpanzees were first immunized with either a recombinant vaccinia virus expressing the envelope glycoproteins of HIV strain LAV-1 (v-env5) or a control recombinant Vaccinia virus and were then challenged with a high or low dose of LAv-1 indicate that immunization did not prevent infection by HIV.
Journal Article
Induction of cytotoxic T lymphocytes specific for a syngeneic tumor expressing the E6 oncoprotein of human papillomavirus type 16.
Lieping Chen,Mark T. Mizuno,Mitra C. Singhal,Hu Shiu-Lok,Denise A. Galloway,Ingegerd Hellström,Karl Erik Hellström +6 more
TL;DR: Data from a murine model established to study the CTL responses to the E6 oncoprotein of HPV-16 support the conclusion that tumor cells associated with HPV- 16 can be inhibited by CTL specific for molecules encoded by the HPV-15 E6 and E7 genes.
Journal ArticleDOI
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.
Ignacio Melero,Mitra C. Singhal,Patrick McGowan,Harald S. Haugen,James Blake,Karl Erik Hellström,Guchen Yang,Christopher H. Clegg,Lieping Chen +8 more
TL;DR: The results suggest that the Tg mice were immunologically ignorant of HPV oncoproteins with respect to a CTL response and that a similar type of ignorance may explain why HPV-associated cervical cancer cells can escape immunological destruction.
Journal ArticleDOI
Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes
Lieping Chen,Stephanie Ashe,Mitra C. Singhal,Denise A. Galloway,Ingegerd Hellström,Karl Erik Hellström +5 more
TL;DR: It is demonstrated that expression of oncogenic proteins of HPV-16 can cause tumor metastasis and implicate HPV- 16 in an important role regarding the progression of HPV -associated human cancers.