In this paper, we study the reversible electroporation process on the normal and cancerous cervical cell. The 2D contour of the cervical cells is extracted using image processing techniques from the Pap smear image. The conductivity change in the cancer cell model has been used to differentiate the effects of the high-frequency electric field on normal and cancerous cells. The cells modulate themselves when this high-frequency pulse is applied based on the Debye relaxation relation. To computationally visualize the effects of the electroporation on the cell membrane Smoluchowski equation calculates the number of pores generated and Maxwell equations are used to determine the Transmembrane potential generated on the membrane of the cervical cell. The results produced demonstrates that this mathematical model perfectly describes the numerical tool to study the normal cells and cancerous cells under the electric field. The electric field is provided with the help of a realistic pulse generator which is designed on the principle of Marx circuit and avalanche transistor-based operations to produce a Gaussian pulse. The paper here uses a strength-duration curve to differentiate the electric field and time in nanoseconds required to electroporate normal and cancerous cells.

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Reversible electroporation study of realistic normal and cancerous cervical cells model using avalanche transistor-based nanopulse generator

Use of Pulse Power Generators with high voltage magnitudes and low-rise times is prominent in industries such as medicine and laser where high technological requirements are needed. The compact design of these generators and the ability for an adjustable rise time of their output is important due to the necessities of these equipment. Accordingly, this paper addresses the compact design of pulse generators in respect to the avalanche breakdown phenomenon in Bipolar Junction Transistors (BJT) while also addressing the effects of different variables in the circuit design of these generators in the environment of the PSpice simulation software. For this purpose, a model circuit was designed and built while a comparison between the outputs from the built model and the outputs of the simulation study was performed in order to ascertain the results.

Mohamad Reza Tajik

Papers

Design, Simulation and Performance Comparison of Pulse Power Generator based on the Avalanche Breakdown Phenomenon in Bipolar Junction Transistors