The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.

The Pharmacological Basis of Therapeutics

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Methods Of Enzymatic Analysis

Metal Ions in Biological Systems

Catechol oxidase and phenoxazinone synthase: Biomimetic functional models and mechanistic studies

Host-guest chemistry has its origin in biological processes involving molecular recognition through noncovalent interactions, as for example when substrates bind to enzymes. Over the last decade, organic capsules and self-assembled coordination cages have been prepared that are able to encapsulate a variety of guests, increase the rates of chemical reactions, change the course of reactions involving encapsulated molecules, or shift equilibria to stabilize otherwise unstable species. Self-assembled metal-organic capsules based on chiral ligands are of special interest because they possess a chiral internal void which can not only enable enantioselective guest recognition and separation but can also provide an asymmetric microenvironment for stereoselective reactions. Small guest molecules have been observed to be encapsulated by a water-soluble self-assembled tetrahedral M4L6 cage prepared via subcomponent self-assembly from amine, aldehyde and Fe precursors. Here we show how the use of a longer diamino terphenylene subcomponent, bearing chiral glyceryl groups, allows the enantioselective formation of larger water-soluble Fe4L6 capsules. This new cage encapsulates a wider range of guests, including larger molecules such as chiral natural products. We also demonstrate our cage’s ability to accelerate catalytically the hydrolysis of the acetylcholine esterase inhibitor insecticide dichlorvos, which shares key chemical features with the class of organophosphate chemical warfare agents (CWAs). Diaminoterphenylenes 4, SS-4, and RR-4 were prepared in three steps from diiodohydroquinone 1 as shown in Scheme 1. The studies described below were carried out using aqueous stock solutions of-5 (or-5 or 5) prepared from enantiopure SS-4 (or RR-4 or 4), 2-formylpyridine, and FeSO4 in a 6 : 12 : 4 ratio (Scheme 2). Experimental details and characterization data are provided in the Supporting Information (SI). A solution of the deep purple capsule-5 gave FTICR mass spectra consistent with an [Fe4L6] formulation (SI Fig. SS09). Its hydrodynamic radius, determined from DOSY NMR, was 15.25 (± 0.62) Å, which is consistent with the value of 16.1 Å derived from the model showin in Figure 1. This model was energy-minimized using the universal force field (UFF) of ArgusLabs (SI Fig. S005). Scheme 1. (a) i. NaOH, EtOH, ii. 3-chloro-1,2-propanediol; (b) 4nitrophenylboronic acid, K2CO3, 0.05 mol% [2,6-bis[(di-1piperidinylphosphino)amino]phenyl] palladium(II) chloride; (c) H2, 10% Pd / C.

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Enantiopure water-soluble [Fe4L6] cages: host-guest chemistry and catalytic activity.

Flexible polystyrene/graphene composites with epsilon-near-zero properties

Overview of MXene and conducting polymer matrix composites for electromagnetic wave absorption

Constructing nickel chain/MXene networks in melamine foam towards phase change materials for thermal energy management and absorption-dominated electromagnetic interference shielding

Laccase immobilized on functionalized cellulose nanofiber/alginate composite hydrogel for efficient bisphenol A degradation from polluted water

Dielectric properties and electromagnetic simulation of molybdenum disulfide and ferric oxide-modified Ti3C2TX MXene hetero-structure for potential microwave absorption

Mohamed M. Ibrahim

Papers

Flexible polystyrene/graphene composites with epsilon-near-zero properties

Overview of MXene and conducting polymer matrix composites for electromagnetic wave absorption

Constructing nickel chain/MXene networks in melamine foam towards phase change materials for thermal energy management and absorption-dominated electromagnetic interference shielding

Laccase immobilized on functionalized cellulose nanofiber/alginate composite hydrogel for efficient bisphenol A degradation from polluted water

Dielectric properties and electromagnetic simulation of molybdenum disulfide and ferric oxide-modified Ti3C2TX MXene hetero-structure for potential microwave absorption