Mohamed Marzouk

TL;DR: A new series of quinazoline derivatives was synthesized and characterized via physicochemical and spectral means and exhibited significant in vitro cytotoxicity against both HeLa and MDA-MB231 cancer cell lines.

TL;DR: The obtained findings revealed that the triazoloquinazolines 30, 36 and 38-40 have superiority among all compounds, demonstrating the highest capacity to deplete 1,1-diphenyl-2-picryl hydrazyl and free radicals, in relation to butylated hydroxyl toluene, as a synthetic antioxidant agent.

TL;DR: It is shown that some benzo[g]traizoloquinazolines displayed remarkable antimicrobial activity and could be used as template for further design of potent antimicrobial agent.

TL;DR: A new class of potent α-glucosidase inhibitors was identified, and the molecular docking predicted plausible binding interaction of the targets in the binding pocket of α- glucose and rationalized the structure-activity relationship (SARs) of the target compounds.

TL;DR: The obtained results indicate promising anti-arthritic activity for compounds 9 and 15 as significant reduction of the serum level of interleukin-1 β [IL-1β], cyclooxygenase-2 [COX-2] and prostaglandin E2 [PGE2] was observed in CFA rats.