M
Mohammad Aslam Khan
Researcher at University of South Alabama
Publications - 47
Citations - 1548
Mohammad Aslam Khan is an academic researcher from University of South Alabama. The author has contributed to research in topics: Pancreatic cancer & Medicine. The author has an hindex of 16, co-authored 38 publications receiving 1020 citations. Previous affiliations of Mohammad Aslam Khan include Council of Scientific and Industrial Research.
Papers
More filters
Journal ArticleDOI
Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications.
Girijesh Kumar Patel,Mohammad Aslam Khan,Haseeb Zubair,Sanjeev K. Srivastava,Moh’d Khushman,Seema Singh,Ajay P. Singh +6 more
TL;DR: The efficacy of four kits from Invitrogen, 101Bio, Wako and iZON along with conventional ultracentrifugation-based method for exosome yield, purity and quality are compared to serve as a guide to choose and further optimize exosomal isolation methods for their desired downstream applications.
Journal ArticleDOI
Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK.
Girijesh Kumar Patel,Mohammad Aslam Khan,Arun Bhardwaj,Sanjeev K. Srivastava,Haseeb Zubair,Mary C. Patton,Seema Singh,Moh’d Khushman,Ajay P. Singh +8 more
TL;DR: A novel role of exosomes in mediating the acquired chemoresistance of PC cells is established and either the functional suppression of miR-155 or restoration of DCK led to marked abrogation of Gem-Exo-mediatedChemoresistance.
Journal ArticleDOI
Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch
Haseeb Zubair,Shafquat Azim,Aamir Ahmad,Mohammad Aslam Khan,Girijesh Kumar Patel,Seema Singh,Ajay P. Singh +6 more
TL;DR: This work discusses select phytochemicals—curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, plumbagin and honokiol—in the context of their reported effects on the processes of inflammation and oxidative stress, which play a key role in tumorigenesis.
Journal ArticleDOI
Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival.
TL;DR: Among all subfractions, SEV was the most bioactive in promoting the survival of hypoxic PC cells and hypoxia‐inducible factor‐1α stabilization was involved in heightened EV release under Hypoxia and for their potency to promote hypoxic cell survival.
Journal ArticleDOI
Racial disparities in prostate cancer: a molecular perspective.
Arun Bhardwaj,Sanjeev K. Srivastava,Mohammad Aslam Khan,Vijay Kumar Prajapati,Seema Singh,James E. Carter,Ajay P. Singh +6 more
TL;DR: This work attempts to provide a molecular perspective on prostate cancer racial disparities by gathering available information on these associated factors and discussing their potential significance in disproportionate incidence and clinical outcomes.