Mohammad Nabil Abo-Zeid

TL;DR: A novel, fast, simple, ultrasensitive and cost‐effective spectrofluorimetric method designed for determination of DCS and LDS in miscellaneous matrices was designed and validated in compliance with ICH guidelines and US‐FDA guidelines.

TL;DR: In vitro and in vivo application of the proposed HPTLC method was applied to simultaneous quantitation of sofosbuvir and daclatasvir in real hepatitis C patients' plasma with good percentage recovery.

TL;DR: The proposed HPTLC method represents a simple, high sample throughput and economic alternative to the already existing more complicated reported LC-MS/MS techniques and would afford an efficient tool for therapeutic drug monitoring and bioavailability studies of SOF and LDS.

TL;DR: A fast and efficient HPLC‐UV method was developed, validated and applied for simultaneous determination of SOF and DCS in pharmaceutical formulations and biological fluids based on coupling liquid‐liquid extraction with ultrasound and dual wavelength detection, which provided simple, sensitive, specific and cost‐effective determination of the SOF‐DCS mixture with good recoveries of the analytes from plasma.

TL;DR: In this article, a fast high-performance thin-layer chromatography (HPTLC) method was developed, validated and applied for simultaneous determination of SOF and ledipasvir in biological matrix.