M
Monica Bubenick
Researcher at Shire plc
Publications - 1
Citations - 193
Monica Bubenick is an academic researcher from Shire plc. The author has contributed to research in topics: Structure–activity relationship. The author has an hindex of 1, co-authored 1 publications receiving 176 citations.
Papers
More filters
Journal ArticleDOI
Discovery of 4-Aryl-4H-chromenes as a New Series of Apoptosis Inducers Using a Cell- and Caspase-Based High Throughput Screening Assay. 4. Structure–Activity Relationships of N-Alkyl Substituted Pyrrole Fused at the 7,8-Positions
William Kemnitzer,John Drewe,Songchun Jiang,Hong Zhang,Candace Crogan-Grundy,Denis Labreque,Monica Bubenick,Giorgio Attardo,Real Denis,Serge Lamothe,Henriette Gourdeau,Ben Tseng,Shailaja Kasibhatla,Sui Xiong Cai +13 more
TL;DR: A methyl group substituted at the nitrogen in the 7-position of the pyrrole ring led to a series of potent apoptosis inducers with potency in the low nanomolar range and they inhibited tubulin polymerization, indicating that methylation of the7-position nitrogen does not change the mechanism of action of these chromenes.