Mónica Fernández-Monreal

TL;DR: It is shown that continuous synthesis and availability of phosphatidylinositol-(3,4,5)-trisphosphate at the postsynaptic terminal is necessary for sustaining synaptic function in rat hippocampal neurons, specific for synaptic, but not extrasynaptic, AMPA receptors, nor for NMDA receptors.

TL;DR: The functional contribution of receptor recycling versus degradation for LTD in rat hippocampal slices, and their correlation with receptor dephosphorylation is examined, contributing to clarify the fate of AMPARs during LTD and emphasize the importance of membrane sorting decisions to determine the outcome of synaptic plasticity.

TL;DR: It is shown that ZIP4 is upregulated after excitotoxin stimulation of the mouse, male and female, hippocampus, and changes in prosurvival signals support the idea that this sequestration results in neuroprotection.

TL;DR: How a trafficking protein, APPL1, mediates synaptic plasticity events depending on the involvement of PI3K intracellular signaling, rather than on the outcome of the synaptic change (potentiation versus depression).

TL;DR: Surprisingly, it is found that FIP2 operates independently from Rab11 proteins, and acts as a negative regulator of AMPAR synaptic trafficking, and is proposed as a retention–release mechanism that restricts the trafficking of AMPA receptors until LTP induction triggers their release and allows synaptic delivery.