M
Monika Kusio-Kobialka
Publications - 2
Citations - 473
Monika Kusio-Kobialka is an academic researcher. The author has contributed to research in topics: Melanoma & Ipilimumab. The author has an hindex of 2, co-authored 2 publications receiving 386 citations.
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Journal ArticleDOI
Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients
Emanuela Romano,Monika Kusio-Kobialka,Periklis G. Foukas,Petra Baumgaertner,Christiane Meyer,Pierluigi Ballabeni,Olivier Michielin,Benjamin Weide,Pedro Romero,Daniel E. Speiser +9 more
TL;DR: It is shown, to the knowledge for the first time, that ipilimumab can engage ex vivo FcγRIIIA (CD16)-expressing, nonclassical monocytes resulting in ADCC-mediated lysis of regulatory T cells (Tregs).
Journal ArticleDOI
FcgRIIIA (CD16)-expressing monocytes mediate the depletion of tumor-infiltrating Tregs via Ipilimumab-dependent ADCC in melanoma patients.
Emanuela Romano,Monika Kusio-Kobialka,Periklis G. Foukas,Helene Bichat,Petra Baumgaertner,Christiane Meyer,Pierluigi Ballabeni,Olivier Michielin,Benjamin Weide,Pedro Romero,Daniel E. Speiser +10 more
TL;DR: It is shown, for the first time, that Ipilimumab leads to the depletion in vitro of Tregs via an antibody-dependent-cellular-cytotoxicity (ADCC) mechanism, selectively mediated by FcgRIIIA (CD16)-expressing, nonclassical monocytes (CD14+CD16++).