Temperature-controlled diffusional active agent dispensers that use a side-chain crystallizable polymer in a form that is not free to flow above its melt temperature as a rate-controlling matrix are disclosed. The polymer may be crosslinked to render it nonflowable, be supported, or grafted to a permeable support. Elements that facilitate or permit heating by radiation or electrical conductance/inductance may be included in the dispenser. At temperatures below the melt temperature of the polymer, the polymer is substantially impermeable to the agent. At tempertures at or above the melt temperature the polymer is substantially permeable to the agent.

Temperature-controlled active agent dispenser

The invention provides a disposable programmable ECG sensor patch for the non-invasive detection of risk patterns according to programmed criteria. The patch is programmed by a medical professional to select one or more monitoring parameters for detection and alarm indication. One application is to detect changes in the ECG due to cardioactive drugs. Another application is triggering an alarm for a cardiac patient during a stress condition. The programmable patch operates in conjunction with an external programming unit for selecting the detection monitoring parameters.

Programmable ECG sensor patch

A high molecular weight drug is transdermally administered by applying a polymer skin enhancer and a drug active to the skin of the patient. The drug active has a molecular weight of above 50 daltons and takes at least 15% by weight of the system. The drug may be encapsulated or the drug solution may be partly encapsulated and partly free. The skin enhancer is polyvinylpyrrolidone (PVP) and it is mixed at between 7 and 35% of the drug. A gelling agent may be optionally added at up to 20% by volume. The chemical system is preferably administered via a multidose transdermal drug patch assembly which includes a drug-impervious support impressed to form a series of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The support is adhesively secured to the skin of a patient. Individual devices are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing devices are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. The drug may also be administered in a creme.

Method of transdermally administering high molecular weight drugs with a polymer skin enhancer

A drug delivery system for transdermally delivering drugs through a given skin area is provided. The delivery system comprises a collapsible container for containing the drug. The container has a drug release opening. A displaceable member is in engagement with the container for expelling the drug from the container via the release opening. A driver is connected with said displaceable member so as to drive the same towards the collapsible container. Conduits are disposed between the release opening and the skin area for conducting the drug to the skin area. An ultrasonic transducer is disposed in the general conduit area for generating ultrasonic waves aimed at the skin area. An ultrasonic waveform generator drives the transducer and an electric control circuit is connected to the flow control for electrically activating the flow control.

Electronic transdermal drug delivery system

The invention provides a disposable sensor patch for non-invasive monitoring and recording of infrequent cardiac events. The patch is thin and flexible for comfortable wear on the person's chest for automatic analysis and recording of ECG. The patch is inexpensive and simple for self-administration. The patch incorporates a battery, ECG amplifier, and a processor for analyzing ECG waveform and recording events. A software algorithm searches for a cardiac abnormality. The patch is designed for continuous long-term wear exceeding 3 days for diagnostic monitoring and exceeding 14 days for event detection. In one embodiment a preformatted report is automatically generated by the patch for wireless transmission to a reporting device such as a generic printer or a wireless network system. The patch may also incorporate a marker switch to correlate recorded ECG data with the patient's perception of a cardiac event.

Disposable extended wear heart monitor patch

A dermal or transdermal patch comprising (1) a backing layer which is non-permeable with respect to a drug formulation to be contained within the patch, (2) a membranous layer, which is permeable to the drug, having a first surface partially in contact with said backing layer so as to define multiple compartments, (3) at least one drug or drug formulation contained within said compartments, (4) an adhesive layer on a second surface of said membranes layer, and (5) a peelable protective cover layer on said adhesive layer.

Multicompartmentalized transdermal patches

Mehrfach Unterteilte Transdermale und Dermale Pflaster

4-15684/+/CGC 1168 MULTICOMPARTMETALIZED DERMAL AND TRANSDERMAL PATCHES Abstract of the Disclosure A dermal or transdermal patch comprising (1) a backing layer which is non-permeable with respect to a drug formulation to be contained within the patch, (2) a membranous layer, which is permeable to the drug, having a first surface partially in contact with said backing layer so as to define multiple compartments, (3) at least one drug or drug formulation contained within said compartments, (4) an adhesive layer on a second surface of said membranous layer, and (5) a peelable protective cover layer on said adhesive layer.

Multicompartmentalized dermal and transdermal patches

L'invention concerne des emplâtres transdermiques ou dermiques pour l'administration d'une quantite controlee de substance active qui se compose : 1. D'une couche de recouvrement 3 fermee et impermeable a la formulation de substance active ; 2. D'une couche permeable 4 a la substance active, constituee d'une matiere membraneuse, qui est liee sur un cote a la couche de recouvrement 3 et forme un reservoir pour la formulation de substance active ; 3. D'un reservoir contenant la formulation de substance active ; 4. D'une couche adhesive 5 sur le cote oppose de la couche permeable 4 a la substance active, qui est tournee vers la surface d'application ; et 5. D'une couche protectrice eliminable 6 sur la couche adhesive, et est caracterisee en ce que le reservoir pour la formulation de substance active est subdivise en plusieurs chambres 8 par des jonctions 9 entre la couche de membrane 4 et la couche de recouvrement 3. (CF DESSIN DANS BOPI)

Moore Donald J

Papers

Multicompartmentalized transdermal patches

Mehrfach Unterteilte Transdermale und Dermale Pflaster

Multicompartmentalized dermal and transdermal patches

Emplatres transdermiques et dermiques comportant plusieurs subdivisions

Multicompartment transdermal patch