M
Murad Alahdal
Researcher at Shenzhen University
Publications - 26
Citations - 365
Murad Alahdal is an academic researcher from Shenzhen University. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 7, co-authored 25 publications receiving 201 citations. Previous affiliations of Murad Alahdal include Hodeidah University & Southern University of Science and Technology.
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Journal ArticleDOI
Up-regulation of miR-210 induced by a hypoxic microenvironment promotes breast cancer stem cell metastasis, proliferation, and self-renewal by targeting E-cadherin
Tingting Tang,Zhaocong Yang,Qinhua Zhu,You Wu,Kun Sun,Murad Alahdal,Yanfeng Zhang,Yun Xing,Yumeng Shen,Tiansong Xia,Tao Xi,Yi Pan,Liang Jin +12 more
TL;DR: Findings reveal a novel regulatory pathway centered on hypoxia‐mediated miR‐210 targeting of E‐cadherin, which contributes to the properties and breast tumorigenesis of BCSCs and develops a novel 3D, semisolid culture system to culture MCF‐7 spheroid cells.
Journal ArticleDOI
Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy
Yuekui Zhao,Shanshan Tang,Jiamin Guo,Murad Alahdal,Shunxiu Cao,Zhaocong Yang,Fangfang Zhang,Yumeng Shen,Minjie Sun,Ran Mo,Li Zong,Liang Jin +11 more
TL;DR: The in vitro and in vivo anti-tumor study has demonstrated that drug loaded MSCs had potent efficacy in lung melanoma metastases treatment and the modified system not only integrates the controlled-release property of nanoparticles but also exhibits tumor tropism and penetrative characteristics of M SCs.
Journal ArticleDOI
Intra-articular injection of hUC-MSCs expressing miR-140-5p induces cartilage self-repairing in the rat osteoarthritis
Yiyun Geng,Chen Jinfu,Murad Alahdal,Murad Alahdal,Chang Chongfei,Li Duan,Weimin Zhu,Lisha Mou,Xiong Jianyi,Manyi Wang,Daping Wang +10 more
TL;DR: Therapeutic superiority of hUC-MSCs overexpressing miR-140-5p to treat OA using intra-articular injection is indicated.
Journal ArticleDOI
Molecular functions of FSTL1 in the osteoarthritis.
Wencui Li,Murad Alahdal,Deng Zhiqin,Liu Jianquan,Zhao Zhe,Cheng Xiangyu,Chen Xiaoqiang,Li Jiabei,Yin Jianwen,Li Yongsheng,Wang Guanghui,Daping Wang,Kanglai Tang,Jiqiang Zhang +13 more
TL;DR: A deep discussion of F STL1's molecular functions in the OA pathophysiology is introduced, which will contribute to the deep understanding of FSTL1 molecular activity in theOA pathogenesis.
Journal ArticleDOI
IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis.
Rongxiang Huang,Rongxiang Huang,Zhang Hui,Zhang Hui,Sun Wei,Duan Li,Wencui Li,Wang Daping,Wang Daping,Murad Alahdal,Murad Alahdal,Murad Alahdal +11 more
TL;DR: The role of IRE1 in cartilage repair and osteoarthritis treatment is discussed in this paper. But the role of the enzyme in cell death and cell death fate remains controversial.