Showing papers by "Murray P. Deutscher published in 2013"

TL;DR: It is shown that four 3′→5′-exoribonucleases, RNases II, R, and PH, and polynucleotide phosphorylase (PNPase), participate in maturation of the 3′ end of 16S rRNA, and in the absence of 3′ maturation, 5′ processing proceeds much less efficiently.

TL;DR: A novel regulatory mechanism affecting RNase R, a 3′ to 5′ exoribonuclease able to act on essentially all RNAs including those with extensive secondary structure is described, indicating a previously unknown role for ribosomes in cellular homeostasis.

TL;DR: It is shown here that the adjacent C residues of the CCA sequence and an Arg residue within a highly conserved sequence motif in the channel leading to the RNase catalytic site are both required for the protective effect of theCCA sequence.