Murtaza Mogri

TL;DR: A primer on the application of optogenetics in neuroscience is provided, focusing on the single-component tools and highlighting important problems, challenges, and technical considerations.

TL;DR: This work used optogenetics and solid-state optics to systematically drive or inhibit an array of distinct circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region.

TL;DR: The first in vivo behavioral demonstration of a functional optical neural interface (ONI) in intact animals is reported, involving integrated fiberoptic and optogenetic technology and may find application across a broad range of neuroscience, neuroengineering and clinical questions.

TL;DR: Examination of the roles of the two subpopulations of nucleus accumbens projection neurons in cocaine reward shows that deletion of TrkB selectively from D1+ or D2+ neurons oppositely affects cocaine reward, providing insight into the molecular control of D1- and D2-containing neuronal activity as well as the circuit-level contribution of these cell types to cocaine reward.

TL;DR: A collection of targeting and readout strategies designed for rapid and flexible application of the microbial opsin system define an evolving toolbox that may open up new possibilities for basic neuroscience investigation.