Dimensional probes of binding and activity

A novel application of photochromic molecules is to mimic physiological oscillatory calcium signals by reversibly binding and releasing calcium ions in response to light. Substituent changes on the largely unexplored photochromic bisbenzospiropyran scaffold led to significant changes in thermal fading rates in several organic solvents. Excellent correlations have been found between fading rates and empirical Hammett constants as well as calculated ground-state energies. These correlations can be used to improve scaffold design.

Substituent Effects on Thermal Decolorization Rates of Bisbenzospiropyrans

Data on the reactions of pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiazine, oxadiazine, and thiadiazine aldoximes, ketoximes, and amidoximes and their derivatives are reviewed. The synthesis of new heterocycles based on the oximes of six-membered heterocyclic compounds with two and three heteroatoms is considered separately. The principal results of research into the biological activity of these oximes and their ethers are also presented.

Oximes of six-membered heterocyclic compounds with two and three heteroatoms. II.* Reactions and biological activity (review)

Regioselective synthesis of 6-alkylated lumazine derivatives

Azoles. part 12. 1 synthesis of thieno-extended purines: First example of the imidazo[4′,5′:4,5]thieno[3,2-d]pyrimidine ring system

O-Phenylation 6-Amino-5-nitroso-1,3-dimethyluracil with Diphenyliodonium Chloride. A New Route to Lumazines

Base-catalyzed Ring Contraction of 6-Imino-5-pheoxyimino-1,3-dimethyluracil to 4,5-Diimino-1,3-dimethylimidazolidin-2(1H)-one. A New Synthesis of Imidazopyrazines

A simple and improved procedure for preparing multi-gram quantities of 2,2'-spirobi[2H-1-benzopyran] (2) is reported. The cyclization of the dihydroxybenzopyran intermediate (1) into 2 proceeded smoothly when a solution of 1 in 2-ethoxyethyl acetate was heated under reflux for 3 hours

Muthiah Inbasekaran

Papers

O-Phenylation 6-Amino-5-nitroso-1,3-dimethyluracil with Diphenyliodonium Chloride. A New Route to Lumazines

Base-catalyzed Ring Contraction of 6-Imino-5-pheoxyimino-1,3-dimethyluracil to 4,5-Diimino-1,3-dimethylimidazolidin-2(1H)-one. A New Synthesis of Imidazopyrazines

An Improved Procedure for the Preparation of 2,2-Spirobi[2H-1-benzopyran]

An Improved Procedure for the Preparation of 2,2′‐Spirobi(2H‐1‐ benzopyran).