A method for producing a carboxylic acid compound represented by the following formula (3) (wherein n is as defined below) is characterized in that an organic layer containing a carboxylic acid compound represented by the above formula (3) is extracted by hydrolyzing a mixture containing an ester compound represented by the following formula (1) (wherein R represents a lower alkyl group and n represents an integer of 1-6) and a compound represented by the following formula (2) (wherein R is as defined above) and then separating the resulting while adjusting the pH from 4 to 8.

Method for producing carboxylic acid compound

PROBLEM TO BE SOLVED: To provide a processing stabilizer for resin.SOLUTION: The processing stabilizer for resin comprises a sulfide compound (2) wherein at least one hydroxy group of a compound (1) represented by CHO(wherein, n is an integer of 3 or more and 10 or less) and having one aldehyde or ketone group and n-1 hydroxy groups is substituted by a -SRgroup (wherein, Rrepresents a Calkyl group or an aromatic group which may have a substituent).

Processing stabilizer for resin, resin composition containing the same, and method for improving processing stability of resin

The invention discloses a new preparation method of a key intermediate, namely 3-amino-2-hydroxyphenylacetone, for preparation of Pranlukast. The new preparation method comprises the following main steps: taking 2-aminophenol-4-sulfonic acid as a starting raw material, and carrying out acylation, Fries rearrangement, hydrolysis and deprotection, so that 3-amino-2-hydroxyphenylacetone is obtained. Compared with the prior art, the new preparation method disclosed by the invention has the advantages that the used raw materials are cheap and easily available, technology can easily realize industrialization, and the obtained final product is high in purity; no danger technology is adopted, and equipment is simple; and route is novel, and synthesis route is short.

New preparation method of 3-amino-2-hydroxyphenylacetone

PROBLEM TO BE SOLVED: To provide a method for easily producing an alicyclic monoolefin carboxylic acid having high purity by a simple process using an easily available crude alicyclic monoolefin carboxylic acid ester as a raw material. SOLUTION: A highly pure alicyclic monoolefin carboxylic acid expressed by formula (II) (R 1 and R 2 are each independently H or a 1-6C hydrocarbon group; and (n) is 1 or 2) is produced by hydrolyzing an alicyclic monoolefin carboxylic acid ester expressed by formula (I) (R 3 is an organic group eliminable by the hydrolysis with an alkali), washing the reaction mixture containing the obtained carboxylic acid alkali salt with a washing solvent composed of an organic solvent immiscible with water and converting the carboxylic acid alkali salt into the corresponding carboxylic acid. COPYRIGHT: (C)2003,JPO

Method for producing alicyclic monoolefin carboxylic acid

PROBLEM TO BE SOLVED: To provide a purification method capable of easily removing residues such as a catalyst or a reaction raw material from a crude composition of 4-hydroxy benzoic acid long chain ester and providing high purity 4-hydroxy benzoic acid long chain ester at high yield.SOLUTION: There is provided a purification method of 4-hydroxy benzoic acid long chain ester including a process for melting a crude composition containing 4-hydroxy benzoic acid long chain ester represented by the formula (1) and a process for mixing the molten crude composition with a mixed solution of water and alcohol and separating them to an organic layer and a water layer and a process for extracting the separated organic layer.SELECTED DRAWING: None

Purification method of 4-hydroxy benzoic acid long chain ester

PROBLEM TO BE SOLVED: To produce the subject high-purity derivative on an industrial scale at a low cost needing no extraction operation by reacting a specific phenylalkyl halide derivative with a specific hydroxybenzoic acid ester derivative under specific conditions SOLUTION: The objective derivative of formula III is obtained by the following process: a phenylalkyl halide derivative of formula I (A is a 2-5C alkylene; X is a halogen) (eg 1-bromo-4-phenylbutane) with a hydroxybenzoic acid ester derivative of formula II (R is a 1-6C alkyl) (eg methyl p-hydroxybenzoate) in the presence of an alkali (hydrogen)carbonate (eg potassium carbonate) in a solvent of isopropyl alcohol at a temperature from 10 degC to the refluxing temperature for about 1 hr to 30 min; the isopropyl alcohol is removed; the resultant product is separated into the aqueous phase and the organic phase, and the aqueous phase is removed; to the organic phase are added water and an alkali (eg sodium hydroxide), and the mixture is treated by hydrolysis at 10-80 degC for about 1 hr to 30 min; and finally, the solution is made weak acidic by adding an acid (eg hydrochloric acid)

Production of benzoic acid derivative

PROBLEM TO BE SOLVED: To obtain the subject derivative by effecting an acid to a butenoic acid derivative obtained by a compound obtained through specific processes with an oxalic acid diester alcolate, and continuing the reaction without isolating an intermediate product. SOLUTION: This method for producing an ester derivative is provided by reacting 3-amino-2-hydroxyacetophenone obtained by aminating with a catalytic reduction of a compound of formula I (X is a halogen) in the presence of a reduction catalyst in an aromatic hydrocarbon solvent, then adjusting pH with a basic substance and dehalogenating with a catalytic reduction, with a benzoic acid halide derivative of formula II (R is a 2-5C alkyl or the like; Y is a halogen) in the presence of an acid eliminating agent of the formula; Mm Bn [M is an alkali (earth) metal; (m), (n) are each positive integer] to obtain a compound of formula III, reacting the compound of formula III with an oxalic acid diester alcolate of the formula: (COOR2 )2 (R2 is a 1-4C alkyl) to obtain a butenoic acid derivative of formula IV and effecting an acid to the compound of formula IV to obtain the compound of formula V.

Production of ester derivative

PROBLEM TO BE SOLVED: To provide a method for manufacturing a dichloro-derivative which gives the dichloro-derivative without accompanying sudden foaming and the like in a short reaction time when a composition for manufacturing a 2,4-dichloro-6-hydroxy-1,3,5-triazine sodium salt (or potassium salt) is dissolved in water. SOLUTION: The composition for manufacturing the 2,4-dichloro-6-hydroxy-1,3,5-triazine sodium salt (or potassium salt) comprises a mixture of a powder of cyanuric chloride and a powder of trisodium phosphate (or tripotassium phosphate). The method for manufacturing the 2,4-dichloro-6-hydroxy-1,3,5-triazine sodium salt (or potassium salt) comprises dissolving the composition in water. COPYRIGHT: (C)2004,JPO&NCIPI

Muto Nobuo

Papers

Production of benzoic acid derivative

Production of ester derivative

Composition for manufacturing 2,4-dichloro-6-hydroxy-1,3,5-triazine sodium salt (or potassium salt)