Method for rendering a preformed article lubricious and antithrombogenic and a device being the same. On the surface of the article a thin coating of a biologically compatible, lubricious, hydrophilic polymer including acid groups, is provided. On the coating, ammonium cation, and heparin are applied in the manner that heparin is bound by electrostatic attraction to the ammonium cation of the coating to permit time release of heparin. A buffer solution may be applied in a manner to act to enhance the lubriciousness of the coating.

Lubricious antithrombogenic catheters, guidewires and coatings

An inflatable balloon (14) for a catheter (10) includes a coating (15) which causes the balloon to prefer a predetermined, low profile configuration, such as a trifold configuration (40), when deflated. The balloon has a wall (13) which has an exterior polymeric coating (15). The coating (15) is set while the balloon is in the predetermined low-profile deflated configuration so that after inflation, the coating acts to urge the balloon to return to the low profile configuration as the balloon is deflated.

Catheter balloon with retraction coating

Plastic articles having enhanced antithrombogenic activity due to the presence of hydrophobic materials attached to amine compounds bonded on the surface of the plastic which repel bonded antithrom bogenic agents outwardly from the plastic surface, making them more readily available to the blood for subsequent thrombus inhibition.

Polymeric articles having enhanced antithrombogenic activity

New and improved lubrifying coatings for reducing the coefficients of friction of surfaces on medical devices include hydrophilic copolymers derived monoethylenically-unsaturated monomers including some monomers having pendant primary amine functionality and some monomers having pendant tertiary amine functionality. The lubricious hydrogel coatings are covalently bondable to epoxy functionalized surfaces on the medical equipment to provide firmly adherent hydrogel coatings that are slippery when wet. Epoxy functionalized surfaces are provided by epoxy functional or epoxy group containing silane coupling agents. The pendant tertiary amine moieties are readily convertible at alkaline pH to quaternary ammonium cations to which anionic anti-thrombogenic agents may be bonded. Three dimensional copolymer matrices may also be provided as coatings on the surfaces by crosslinking the copolymers before or after attachment to the surface being treated.

Lubricious hydrogel surface modification

The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.

Silicone hydrogel lenses with water-rich surfaces

1. AN ANTI-THROMBOGENIC POLYMER COMPOSITION CONSISTING ESSENTIALLY OF WATER-INSOLUBLE CATIONIC COPOLYMERS HAVING MONOMER UNITS COMPRISING (I) HYDROPHILIC COMPONENTS, (II) QUATERNARY AMMONIUM COMPONENTS, (III) HYDROPHOBIC COMPONENTS, AND HEPARIN INTERNALLY BOUND THEREIN, AND HAVING A NEGATIVE STANDARD MEMBRANE POTENTIAL DIFFERENCE, SAID MONOMER UNITS CONSTITUTING THE HYDROPHILIC COMPONENTS (I) BEING SELECTED FROM THE GROUP CONSISTING OF ACRYLIC ACID, METHACRYLIC ACID (MA), A SALT OF MA, AN AMIDE OF MA, AN ALKYLENE GLYCOL ADDUCT OF MA AND VINYLPYRIDINE, THE MONOMER UNITS CONSTITUTING SAID QUATERNARY AMMONIUM SALT COMPONENTS (ii) BEING SELECTED FROM THE GROUP CONSISTING OF DIALKYLDALLYL AMMONIUM HALIDE OR (H2C=C(-R)-COO-(CH2)N-N(-R1)(-R2)-R3)(+) X(-) (WHEREIN N=2 OR 3, R=H OR A HYDROCARBON RADICAL, R1, R2, R3=A HYDROCARBON RADICAL AND X=AN ANIONIC GROUP ABLE TO FORM A SALT WITH AN AMINE NITROGEN, SUCH AS A HALOGEN), AND SAID MONOMER UNITS CONSTITUTING SAID HYDROPHOBIC COMPONENTS BEING SELECTED FROM THE GROUP CONSISTING OF ACRYLIC ACID ESTER, METHACRYLIC ACID ESTER, ACRYLONITRILE, VINYL ACETATE, VINYL CHLORIDE, STYRENE, A-METHYL STYRENE, VINYLIDENE DICHLORIDE, ETHYLENE, PROPYLENE AND BUTADIENE, SAID WATER-INSOLUBLE CATIONIC COPOLYMERS CONSISTING ESSENTIALLY OF A PRECENT BY WEIGHT OF SAID HYDROPHILIC COMPONENT (I), (WHERE 30%$A$2%), B PERCENT BY WEIGHT OF SAID QUATERNARY AMMONIUM SALT COMPONENTS, AND C PERCENT BY WEIGHT OF SAID HYDROPHOBIC COMPONENTS (III) (WHEREIN 40%$C$2% AND 50%$A+C$10%), (WHERE C+A+B=100%).

N Harumiya

Papers

Shampooer with rotary foam generating means anti-thrombogenic polymer compositions with internally bound heparin