Cyclizations of N-acyliminium ions.

Intramolecular reactions of N-acyliminium intermediates

A novel method for the synthesis of oxindoles is described. In the presence of catalytic palladium acetate and 2-(di-tert-butylphosphino)biphenyl, α-chloroacetanilides are converted to oxindoles in good to excellent yields with high functional group compatibility using triethylamine as a stoichiometric base. The cyclization is highly regioselective, obviating the need for prefunctionalized arenes. Plausible mechanistic pathways for the reaction are discussed.

Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization

The reaction of vinyl grignard reagents with 2-substituted nitroarenes: A new approach to the synthesis of 7-substituted indoles

An sp(2)/sp(3) get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl C(sp(2))-H and a C(sp(3))-H center (see scheme; DMF = N,N-dimethylformamide).

Oxindole synthesis by direct coupling of C(sp2)-H and C(sp3)-H Centers

Intra vs intermolecular amidoalkylation of aromatics

Inter vs intramolecular amidoalkylations of aromatics - a new synthesis of oxindoles, isoquinolones and benzazepinones

Amidoalkylation of Aromatic Compounds with Chloral Derivatives

Amidoalkylation of aromatic compounds with chloral derivatives

Intra vs. Intermolecular Amidoalkylation of Aromatics.

N. Peled

Papers

Intra vs intermolecular amidoalkylation of aromatics

Inter vs intramolecular amidoalkylations of aromatics - a new synthesis of oxindoles, isoquinolones and benzazepinones

Amidoalkylation of Aromatic Compounds with Chloral Derivatives

Amidoalkylation of aromatic compounds with chloral derivatives

Intra vs. Intermolecular Amidoalkylation of Aromatics.