N
N. Walsh
Researcher at University of Queensland
Publications - 3
Citations - 395
N. Walsh is an academic researcher from University of Queensland. The author has contributed to research in topics: Tartrate-resistant acid phosphatase & Acid phosphatase. The author has an hindex of 3, co-authored 3 publications receiving 374 citations.
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Journal ArticleDOI
Structure, function, and regulation of tartrate-resistant acid phosphatase.
G.W. Oddie,Gerhard Schenk,Nicola Angel,N. Walsh,Luke W. Guddat,J. de Jersey,A. I. Cassady,Susan E. Hamilton,David A. Hume +8 more
TL;DR: The view that TRAP, like several other hydrolases, is synthesized as a relatively inactive proen enzyme, and cleavage is the physiological mechanism of proenzyme activation in osteoclasts is put forth.
Journal ArticleDOI
Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover.
TL;DR: Measurements of the bone formation rate suggest that the animals compensate for the increased resorption by increasing bone synthesis, which partly ameliorates the phenotype, and provides evidence that inclusion of an irrelevant enhancer does not necessarily override a tissue‐specific promoter.
Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover
A. I. Cassady,N. Walsh,Nicola Angel,Marian M. Cahill,Mark R. Forwood,Michael C. Ostrowski,David A. Hume +6 more
TL;DR: Tartrate resistant acid phosphatase (TRAP) is a secreted product of osteoclasts and a lysosomal hydrolase of some tissue macrophages as discussed by the authors.