N
Na Che
Researcher at Tianjin Medical University
Publications - 30
Citations - 990
Na Che is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Vasculogenic mimicry & Medicine. The author has an hindex of 14, co-authored 21 publications receiving 855 citations. Previous affiliations of Na Che include Tianjin Medical University General Hospital.
Papers
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Journal ArticleDOI
Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry.
Tao Sun,Nan Zhao,Xiu Lan Zhao,Qiang Gu,Shi Wu Zhang,Na Che,Xing Hui Wang,Jing Du,Yi xin Liu,Baocun Sun +9 more
TL;DR: Investigation of HCC as a VM and EMT model indicates that Twist1 induces HCC cell plasticity in VM cells more through the suppression of E‐cadherin expression and the induction of VE‐c cadherin up‐regulation than through the VM pattern in vivo and in a three‐dimensional in vitro system.
Journal ArticleDOI
Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma.
Tao Sun,Baocun Sun,Xiu Lan Zhao,Nan Zhao,Xue Yi Dong,Na Che,Zhi Yao,Yue Mei Ma,Qiang Gu,Wen Kang Zong,Zhiyong Liu +10 more
TL;DR: A novel function of Bcl‐2 in EMT induction is described, insight into tumor progression is provided, and the B cl‐2/Twist1 complex is implicate as a potential target for developing chemotherapeutics.
Journal ArticleDOI
Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial‐mesenchymal transition regulator Twist1
TL;DR: It is indicated that Twist1 induces HCC invasion via increased activity in MMPs, leading to poor clinical prognoses, and a novel cogitation in Twist2, which has no effect on H CC invasion and metastasis.
Journal ArticleDOI
Slug promoted vasculogenic mimicry in hepatocellular carcinoma.
Dan Sun,Baocun Sun,Tieju Liu,Xiulan Zhao,Na Che,Qiang Gu,Xueyi Dong,Zhi Yao,Rui Li,Jing Li,Jiadong Chi,Ran Sun +11 more
TL;DR: It is demonstrated that slug expression was associated with EMT and cancer stem cell (CSCs) phenotype in HCC patients and slug overexpression lead to the maintenance of CSCs phenotype and VM formation was demonstrated in vivo.
Journal ArticleDOI
Dickkopf-1-promoted vasculogenic mimicry in non-small cell lung cancer is associated with EMT and development of a cancer stem-like cell phenotype
Lingli Yao,Danfang Zhang,Xiulan Zhao,Baocun Sun,Yanrong Liu,Qiang Gu,Yanhui Zhang,Xueming Zhao,Na Che,Yanjun Zheng,Fang Liu,Yong Wang,Jie Meng +12 more
TL;DR: In vivo animal studies demonstrated that DKK1 enhances the growth of transplanted human tumours cells, as well as increased VM formation, mesenthymal phenotypes and CSC properties, and it is felt that Dkk1 may represent a novel target of NSCLC therapy.