N
Nadine Chan
Researcher at Lawrence Berkeley National Laboratory
Publications - 2
Citations - 165
Nadine Chan is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Alternative splicing & Gene. The author has an hindex of 2, co-authored 2 publications receiving 164 citations.
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Molecular and Functional Characterization of Protein 4.1B, a Novel Member of the Protein 4.1 Family with High Level, Focal Expression in Brain
Marilyn Parra,Philippe Gascard,Loren D. Walensky,J. Aura Gimm,Seth Blackshaw,Nadine Chan,Yuichi Takakuwa,Trish Berger,Gloria Lee,Joel Anne Chasis,Solomon H. Snyder,Narla Mohandas,John G. Conboy +12 more
TL;DR: Results indicate that 4.1B transcription is selectively regulated among neuronal populations and that alternative splicing regulates expression of 4.2B isoforms possessing critical functional domains typical of other protein 4.
Journal ArticleDOI
Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms
Marilyn Parra,Sherry Gee,Nadine Chan,Dmitriy Ryaboy,Inna Dubchak,Narla Mohandas,Philippe Gascard,John G. Conboy +7 more
TL;DR: Comparative genomic and transcript analysis of these EPB41 genes indicates several unusual features: differential evolution of highly conserved exons encoding known functional domains interspersed with unique exons whose size and sequence variations contribute substantially to intergenic diversity.