Najeeb-ur-Rehman

TL;DR: The results suggest that the spasmolytic and vasodilator effects of Mc.Cr root extract are mediated possibly through blockade of voltage-dependent calcium channels and release of intracellular calcium, which may explain the medicinal use of Morinda citrifolia in diarrhea and hypertension.

TL;DR: In this article, the aqueous-methanolic extract of Lepidium sativum seeds (Ls.Cr) at 30 and 100mg/kg showed atropine-sensitive prokinetic and laxative activities in mice.

TL;DR: It is suggested that Juniperus excelsa possibly exhibits a combination of Ca2+ antagonist and phosphodiesterase inhibitory effects, which provides a pharmacological basis for its traditional use in disorders of gut and airways hyperactivity, such as diarrhoea, colic and asthma.

TL;DR: This study shows the prokinetic, laxative and spasmodic effects of the plant extract partially mediated through cholinergic pathways with species and tissue-selectivity, and provides a sound rationale for the medicinal use of Fumaria parviflora in gut motility disorders.

TL;DR: Showing the presence of antidiarrheal, antispasmodic and bronchodilator activities in Fumaria parviflora possibly mediated through dual blockade of muscarinic receptors and Ca(2+) channels provides sound basis for its medicinal uses in diarrhea, abdominal cramps and may be used as bronchidilator in asthma.