Nan Zhang

TL;DR: Findings provide direct evidence that fast neuroprotection by estradiol is partially mediated by GPR30 and the subsequent downregulation of NR2B-containing NMDARs and the modulation of DAPK1 activity by G PR30 may be an important mediator of estradio-dependent neuroprotection.

TL;DR: The results indicate that estradiol reduces anxiety-like behaviors induced by acute stress at least partially through GPR30 signaling, maintaining the balance between GABAergic and glutamatergic transmission in the BLA of OVX-stressed mice.

TL;DR: The neuroprotective effects of these two analogues show that Tyr has a better antioxidative action compared with Sal both in vivo and in vitro, and suggest that the antioxidant activity of Sal and Tyr may be partly due to their different substituents in their glycosyl groups.

TL;DR: The aim of the present study was to investigate the role of G‐protein‐coupled receptor 30 (GPR30), a new kind of oestrogen receptor, in the neuroprotection against oxidative insult.

TL;DR: This study provides strong evidence that Gent inhibits reserpine-induced pain/depression dyad by downregulating GluN2B receptors in the amygdala and reverses the changes in the levels of biogenic amines, caspase-3, and Glun2B-containing NMDA receptors in amygdala.