Showing papers by "Nancy M. Dahms published in 2000"
TL;DR: The results demonstrate that the IGF-II/MPR contains two functionally distinct CRDs, which differ dramatically in their ability to recognize the distinctive modifications found on Dictyostelium discoideum lysosomal enzymes: the amino-terminal CRD binds mannose 6-sulfate and Man-6-P methyl ester with a 14-55-fold higher affinity than the carboxyl- terminal CRD.
Abstract: The insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/MPR) is a type I glycoprotein that mediates both the intracellular sorting of lysosomal enzymes bearing mannose 6-phosphate (M...
45 citations