N
Natale Figura
Researcher at University of Siena
Publications - 214
Citations - 7869
Natale Figura is an academic researcher from University of Siena. The author has contributed to research in topics: Helicobacter pylori & CagA. The author has an hindex of 39, co-authored 214 publications receiving 7569 citations. Previous affiliations of Natale Figura include Keio University & University of Bologna.
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Journal ArticleDOI
Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
Antonello Covacci,Stefano Censini,M Bugnoli,R. Petracca,Daniela Burroni,G. Macchia,A. Massone,Emanuele Papini,Z Xiang,Natale Figura +9 more
TL;DR: The nucleotide sequence and expression of an immunodominant antigen of H. pylori and the immune response to the antigen during disease are reported and it is suggested that only bacteria harboring this protein are associated with disease.
Journal ArticleDOI
Analysis of expression of caga and vaca virulence factors in 43 strains of helicobacter pylori reveals that clinical isolates can be divided into two major types and that caga is not necessary for expression of the vacuolating cytotoxin
Z Xiang,Stefano Censini,P. F. Bayeli,John L. Telford,Natale Figura,Rino Rappuoli,Andantonello Covacci +6 more
TL;DR: This finding shows that although it is present in most cytotoxic strains, CagA is not necessary for the expression of the vacuolating cytotoxin, and is shown to be independent of VacA.
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Development of a mouse model of Helicobacter pylori infection that mimics human disease.
TL;DR: This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans, and oral immunization with purified H.pylori antigens protected mice from bacterial infection.
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Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.
Natale Figura,P. Guglielmetti,Aldo Rossolini,A Barberi,G Cusi,R. A. Musmanno,M. Russi,S. Quaranta +7 more
TL;DR: A total of 66.6% of Campylobacter pylori strains isolated from patients with peptic ulcers produced a cytotoxin active against mammalian cells in vitro, which suggests that the toxic substance could be involved in the development of peptic Ulcers.
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CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines.
TL;DR: H pylori directly increases gastric epithelial IL-8 mRNA expression andIL-8 protein secretion in a strain specific manner and may explain the association between CagA/cytotoxin positive strains and gastroduodenal disease.