Natalja Strelkowa

TL;DR: This paper discusses and applies an ABC method based on sequential Monte Carlo (SMC) to estimate parameters of dynamical models and develops ABC SMC as a tool for model selection; given a range of different mathematical descriptions, it is able to choose the best model using the standard Bayesian model selection apparatus.

TL;DR: It is shown that influenza A (H3N2) evolves by strong clonal interference, implying that mode and speed of influenza evolution are governed not only by positive selection within, but also by background selection outside antigenic epitopes: immune adaptation and conservation of other viral functions interfere with each other.

TL;DR: Even repressilators possess quasi-stable, travelling wave periodic solutions that are reachable, long-lived and robust to parameter changes that underlie the sustained oscillations observed in even rings in the stochastic regime, even if these circuits are expected to behave as switches.

TL;DR: The applications of synthetic biology will involve the release of artificial life forms into the environment that present unique safety challenges that need to be addressed by researchers and regulators to win public engagement and support.

TL;DR: It is shown that the family of unstable orbits possesses spatial symmetries and can also be understood in terms of traveling wave solutions of kink-like topological defects, and the long-lived oscillatory transients correspond to the propagation of quasistable two-kink configurations that unravel over a long time.