N
Nathalie Dehne
Researcher at Goethe University Frankfurt
Publications - 45
Citations - 2096
Nathalie Dehne is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Hypoxia-inducible factors & Gene knockdown. The author has an hindex of 24, co-authored 45 publications receiving 1763 citations. Previous affiliations of Nathalie Dehne include University of Duisburg-Essen.
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Journal ArticleDOI
Redox control of inflammation in macrophages.
Bernhard Brüne,Nathalie Dehne,Nina Grossmann,Michaela Jung,Dmitry Namgaladze,Tobias Schmid,Andreas von Knethen,Andreas Weigert +7 more
TL;DR: The mechanisms how redox signals add to the process of Macrophage polarization and reprogramming are summarized, how this is controlled by the interaction of macrophages with their environment, and the outcome of the polarization process in health and disease are addressed.
Journal ArticleDOI
HIF-1 in the inflammatory microenvironment
Nathalie Dehne,Bernhard Brüne +1 more
TL;DR: In this article, a review summarizes mechanisms of HIF activation in mammalian immune cells, especially in macrophages and neutrophils, and outlines how HIF moderates inflammation, showing that multiple pathways in the inflammatory microenvironment are used to adjust HIF-1alpha levels to affect macrophage biology.
Journal ArticleDOI
Cancer cell and macrophage cross-talk in the tumor microenvironment.
TL;DR: How hypoxia and cell death adds the cross‐talk between cancer cells and macrophages is discussed.
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Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
Christian Werno,Heidi Menrad,Andreas Weigert,Nathalie Dehne,Sergij Goerdt,Kai Schledzewski,Julia Kzhyshkowska,Bernhard Brüne +7 more
TL;DR: The data suggest that Hif-1α-deficient MФs develop a more prominent TAM marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs.
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Roles of hypoxia‐inducible factor‐1α (HIF‐1α) versus HIF‐2α in the survival of hepatocellular tumor spheroids
Heidi Menrad,Christian Werno,Tobias Schmid,Ekaterini Copanaki,Thomas Deller,Nathalie Dehne,Bernhard Brüne +6 more
TL;DR: Enhanced expression of one HIF‐isoform causes a survival advantage in hepatocellular carcinoma development and shifts the balance of Bcl‐2 family members toward survival.