Nathalie Fuentes

TL;DR: This chapter addresses the molecular events governing regulation of gene expression via the nuclear estrogen receptors (ERα, and ERβ) and the membrane estrogen receptor (GPER1) and describes mechanisms of cross-talk between signaling cascades activated by both nuclear and membrane estrogen receptors.

TL;DR: The results indicate that both sex and hormonal status can influence lung miRNA expression in response to ozone exposure, indicating that sex-specific miRNA regulation of inflammatory gene expression could mediate differential pollution-induced health outcomes in men and women.

TL;DR: This mini-review summarized seminal studies aimed to understand the effects of the most relevant male and female sex hormones (estrogens, progesterone, and androgens) and their receptors on lung function and inflammation and reviewed the known influences of sex hormones and of the hypothalamic–pituitary–gonadal axis in lung disease and immunity.

TL;DR: In this article, the authors describe the epidemiology of sex differences in respiratory diseases including neonatal lung disease (respiratory distress syndrome, bronchopulmonary dysplasia) and pediatric and adult disease (including asthma, cystic fibrosis, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, lung cancer, lymphangioleiomyomatosis, obstructive sleep apnea, pulmonary arterial hypertension, and respiratory viral infections such as respiratory syncytial virus, influenza, and SARS-CoV-2).

TL;DR: It is indicated that 17ß-estradiol increases ozone-induced inflammation and AHR in females but not in males, and future studies examining diseases associated with air pollution exposure should consider the patient's sex and hormonal status.