Background Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods In nine countries, we...

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Prevention of HIV-1 Infection with Early Antiretroviral Therapy

Prospective Cohort Study

Secret History: Return of the Black Death Channel 4, 7-8pm In 1348 the Black Death swept through London, killing people within days of the appearance of their first symptoms. Exactly how many died, and why, has long been a mystery. This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale. And they ask, what might be coming next?

Medscape

Background Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations. Methods We conducted a randomized trial of oral antiretroviral therapy for use as preexposure prophylaxis among HIV-1–serodiscordant heterosexual couples from Kenya and Uganda. The HIV-1–seronegative partner in each couple was randomly assigned to one of three study regimens — once-daily tenofovir (TDF), combination tenofovir–emtricitabine (TDF–FTC), or matching placebo — and followed monthly for up to 36 months. At enrollment, the HIV-1–seropositive partners were not eligible for antiretroviral therapy, according to national guidelines. All couples received standard HIV-1 treatment and prevention services. Results We enrolled 4758 couples, of whom 4747 were followed: 1584 randomly assigned to TDF, 1579 to TDF–FTC, and 1584 to placebo. For 62% of the couples followed, the HIV-1–seronegative partner was male. Among HIV-1–seropositive par...

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Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

https://www.commed.vcu.edu/Chronic_Disease/2012/cochranrvwrschbias.pdf

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

The purpose of this systematic review is to provide updated evidence on the preferred induction therapy for the treatment of HIV‐associated cryptococcal meningitis considering the most recent evidence available in order to inform the need for updates to WHO guidelines.

An updated systematic review of HIV‐associated cryptococcal meningitis treatment strategies

Training opportunities in such areas as trauma and infectious disease management should be expanded with a view to supporting health professionals in the region. At the same time, because the majority of health staff in the region will not be fortunate enough to be able to travel to South Africa, training modules should be developed that can be replicated in neighbouring countries.

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How can South Africa's medical profession contribute to humanitarian action?

/pdf/decentralising-hiv-treatment-delivery-in-middle-and-low-4j4riu2vx0.pdf

Decentralising HIV treatment delivery in middle- and low- income countries (Protocol)

Moxifloxacin for Buruli ulcer/HIV-coinfected patients: kill two birds with one stone? Author reply.

Ingrid Eshun-Wilson and colleagues summarize gaps in primary HIV implementation research methods and reporting, and propose areas for future methodological development.

/pdf/strengthening-implementation-guidelines-for-hiv-service-2vnr6zil.pdf

Nathan Ford

Papers

An updated systematic review of HIV‐associated cryptococcal meningitis treatment strategies

How can South Africa's medical profession contribute to humanitarian action?

Decentralising HIV treatment delivery in middle- and low- income countries (Protocol)

Moxifloxacin for Buruli ulcer/HIV-coinfected patients: kill two birds with one stone? Author reply.

Strengthening implementation guidelines for HIV service delivery: Considerations for future evidence generation and synthesis