Navid Goodarzi

TL;DR: This review will focus on polysaccharide drug conjugates and will provide an overview on various conjugation studies which have been accomplished for these carriers with cytotoxic drugs.

TL;DR: Hyaluronic acid–drug conjugates showed specific toxicity only in CD44‐expressing cells in vitro, along with a decreased risk of neutropenia and dose‐dependent mortality in vivo, and represent a promising and efficient platform for solubilization of sparingly soluble molecules.

TL;DR: In vivo studies of DTX‐HSA‐FA andDTX‐ HSA‐biotin conjugates in BULB/c mice, tumorized by 4T1 cell line, showed the conjugate prepared were more powerful in the reduction in tumor size and increasing the survival rate when compared to free docetaxel.

TL;DR: Chitosan-coated HA-DTX nanoparticles were more effective against CD44+ cells than free DTX and showed increased cellular uptake showed by inverted confocal microscope.

TL;DR: For the first time, bio-guided fractionation of the root extract of B. multifida indicates significant sustained anxiolytic effects which led to isolation of three coumarin derivatives with well-known potent MAO inhibitory and anti-anxiety effects.