Showing papers by "Nemat O. Borhani published in 1978"
TL;DR: In any equation relating changes in the levels of plasma cholesterol to the changes in synthesis, absorption and elimination of cholesterol from the body pools the authors must consider the "transport" of cholesterol by lipoproteins and their metabolism.
Abstract: The most commonly used methods to study the mechanisms of hypocholesterolemic action of therapeutic agents generally determine the turnover of total (exchangeable) cholesterol pools in the body. This approach is based on the view that whatever increases the total load of cholesterol in the body will increase the levels of plasma cholesterol, and vice versa. Despite the importance of this assumption it has never been tested, and there is no evidence to indicate that it is valid under all conditions.
2 citations
TL;DR: From 1962 to 1975 the incidence of leukemia in Shasta County and in a comparison county (Placer) were only slightly higher than expected, and no significant differences between observed and expected numbers of patients were observed in communities in both counties.