N
Nicholas J. Rettko
Researcher at University of Wisconsin-Madison
Publications - 2
Citations - 95
Nicholas J. Rettko is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Peptide sequence & Receptor. The author has an hindex of 2, co-authored 2 publications receiving 75 citations.
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Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold
James W. Checco,Dale F. Kreitler,Nicole C. Thomas,David G. Belair,Nicholas J. Rettko,William L. Murphy,Katrina T. Forest,Samuel H. Gellman +7 more
TL;DR: A strategy for designing oligomers containing both α- and β-amino acid residues (“α/β-peptides”) that mimic several peptides derived from the three-helix bundle “Z-domain” scaffold that should enable the design of biostable α/ β- peptides that bind tightly and specifically to diverse targets of biomedical interest.
Journal ArticleDOI
Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy.
James W. Checco,Geoffrey A. Eddinger,Nicholas J. Rettko,Alexander R Chartier,Samuel H. Gellman +4 more
TL;DR: It is discovered that peptide-induced trimer disruption can be promoted by structurally diverse small molecules, including a detergent commonly used during selection procedures, and suggests new avenues for future efforts to block signaling via proteins with an active form that is oligomeric, including other members of the TNFα family.