THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

The Design and Analysis of Experiments

Highway Capacity Manual改訂の動向--テイラ-教授の講演より

BRUNO LATOUR, The pasteurization of France, trans. Alan Sheridan and John Law, Cambridge, Mass., and London, Harvard University Press, 1988, 8vo, pp. 273, £23.95. GEORGES CANGUILHEM, Ideology and rationality in the history of the life sciences, trans. Arthur Goldhammer, Cambridge, Mass., and London, The MIT Press, 1988, 8vo, pp. xi, 160, £17.95. Bruno Latour has written a wonderfully funny book about himself. It is difficult, however, to summarize a text committed to the view that \"Nothing is, by itself, either reducible or irreducible to anything else\", (p. 158). In Latour's opinion, the common view that sociologists of knowledge and scientists are opposed is incorrect. Both groups, according to Latour, are the authors of identical mistakes: reductionism and, relatedly, attempting to conjoin (in the instance of the sociologist) science and society, or (in the instance of the scientist) keeping them apart. For Latour, there are only forces or resistances which different groups encounter and attempt to conquer by forming alliances. These groups, however, are not simply the actors of conventional sociology. They include, for example, microbes, the discovery of the Pasteurians, with which they have populated our world and which we must now take notice of in any encounter or war in which we engage. War is a fundamental metaphor for Latour, since in a war or a battle clashes of armies are later called the \"victory\" of a Napoleon or a Kutuzov. Likewise, he argues, the Pasteurization of France can be viewed as a battle, with its field and its myriad contestants, in which opposing sides attempted to mould and coerce various forces of resistance. Strangely, he points out, the outcome of this huge battle, the labour and struggle of these masses, we attribute to the scientific genius of Pasteur. Pasteur's genius, however, says Latour, lay not in science (for this could be yet another way of making science and society distinct) but as strategist. Pasteur was able to cross disciplinary lines, recruiting allies to laboratory science by persuading them that they were recruiting him. This was possible because, like the armies in battle, they had already done the work of the general. Thus Pasteur's microbiology, which might conventionally be seen as a whole new science, can also be construed as a brilliant reformulation of all that preceded it and made it possible. Hygienists seized on the work of the Pasteurians and the two rapidly became powerful allies because \"The time that they [the hygienists] had made was now working for them\" (p. 52). French physicians, on the other hand, resisted recruitment, since for them it meant enslavement. Finally, however, they recruited the Pasteurians to their enterprise. Pasteurian public health was turned into a triumph of medicine. It is impossible to read this book and not substitute Latour for Pasteur. At the head of his own army, increasingly enlarged by the recruitment of allies, Latour now presents us, in his own language, with something we have made, or at least made possible. The cynic might say, using the old jibe against sociologists, that Latour has explained to us in his own language everything we knew anyway. Retorting thus, however, would be to unselfconsciously make an ally of Latour and miss the point by a narrow margin that might as well be a million miles. Latour says all this much more clearly (and certainly more wittily) than any review. Read it, but beware; in spite of Latour's strictures about irreducibility, the text is not what it seems. This is a recruitment brochure: Bruno needs you. Among the many historians whom Latour convicts by quotation of mistaking the general for the army, Pasteur for all the forces at work in French society, is Georges Canguilhem. Latour uses two quotes from Canguilhem, both taken from the original French version of Ideology and rationality in the life sciences, first published in 1977. Reading Canguilhem after Latour induces a feeling akin to culture shock. Astonishingly, Canguilhem seems almost Anglo-American. Anyone familiar with Canguilhem's epistemological universe would hardly be surprised to discover that Latour finds in it perspectives different from his own. After all, Canguilhem remains committed to the epistemologically distinct entity science or, better still, sciences. Likewise he employs distinctions between science and ideology, as in Spencerian ideology and Darwinian science, which will seem familiar, possibly jaded to English-reading eyes. His text is liberally seeded with unLatourian expressions, including injunctions to distinguish \"between ideology and science\" (p. 39), lamentations that eighteenth-century medicine \"squandered its energy in the erection of systems\" (p. 53), rejoicing that physiology \"liberated itself' from classical anatomy (p. 54), and regret that \"Stahl's influence ... seriously impeded experimental

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Bruno Latour, The pasteurization of France , trans. Alan Sheridan and John Law, Cambridge, Mass., and London, Harvard University Press, 1988, 8vo, pp. 273, £23.95. - Georges Canguilhem, Ideology and rationality in the history of the life sciences , trans. Arthur Goldhammer, Cambridge, Mass., and London, The MIT Press, 1988, 8vo, pp. xi, 160, £17.95.

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desirable AAV capsids, optimizing genome designs and harnessing revolutionary biotechnologies have contributed substantially to the growth of the gene therapy field. Preclinical and clinical successes in AAV-mediated gene replacement, gene silencing and gene editing have helped AAV gain popularity as the ideal therapeutic vector, with two AAV-based therapeutics gaining regulatory approval in Europe or the United States. Continued study of AAV biology and increased understanding of the associated therapeutic challenges and limitations will build the foundation for future clinical success.

/pdf/adeno-associated-virus-vector-as-a-platform-for-gene-therapy-2oljl72lia.pdf

Adeno-associated virus vector as a platform for gene therapy delivery

Effect of door width, platform height and fare collection on bus dwell time. A laboratory study

Object localisation deficits in posterior cortical atrophy and typical alzheimer’s disease: tracking position, movement and fixation patterns within a simulated real-world setting

To begin thinking about how transport affects and is affected by wellbeing, we have to think first about why we have transport at all: what does transport do for us? Only then we can start to think about how to make a transport system work to achieve the outcomes we desire. In particular, this chapter examines the engineering of decision making in the transport system. As the link between planning and engineering is symbiotic we need to see how the relationship works at the level of how we design the transport system in a city to contribute to wellbeing.

Transport and Wellbeing

Throughout Europe, low floor buses are being introduced in order to extend access to more elderly and disabled people. This will be encouraged in the UK by the forthcoming Public Service Vehicles Accessibility Regulations and in Europe in general by the European Bus and Coach Directive. However, this improvement in vehicle specification does little to help people who cannot enter the bus because of deficiencies in the design of bus stops. The need expressed in the COST 322 report (to reduce the horizontal gap between the bus and the platform at a bus stop) is difficult to achieve if the driver is unable to carry out the appropriate maneuvers. The EXCALIBUR project was set up to investigate and test how infrastructure design could be specified so that both of these problems could be eased. EXCALIBUR developed and tested different designs of bus stop infrastructure in order to determine standards for construction of accessible bus stops. The designs were developed based on the outcomes of extensive work with users - elderly and disabled passengers as well as bus drivers. A number of experiments on different designs of bus stop and bus were undertaken at a specially constructed test site in London. The results of these experiments were incorporated in the design and construction of some bus stops in London so that on-street testing with passengers and buses could be observed. This paper describes the outcomes of the EXCALIBUR project. The paper begins with a description of the context of the project. EXCALIBUR is exploring how users’ needs can be incorporated directly in to the design of bus stops so that the resulting infrastructure facilitates the use of accessible buses. The paper then discusses the broad principles for the design of accessible bus stops, extracted from the work with the users and drivers. The on-street tests carried out in East London are then described, including the decisions about the compromises necessary to enable the best design to be built within the constraints of each site. Next, the paper considers the evaluation methodology and discloses the results of the on-street trial. Conclusions are drawn about the benefits of accessible bus stop design to elderly and disabled people, design and construction standards needed for accessible bus stops, the implications for the design of vehicles, training of users and drivers and the next steps for work in this area.

Evaluation of Changes to Bus Stop Design to Benefit Elderly and Disabled People

Buses are the unsung heroes of public transport in modern cities around the world in high,medium and low income countries. However, the bus system is usually cobbled by poordesign which has resulted from poor understanding of how a busThis paper examines theimpacts of the interactions between buses, passengers and traffic on bus operations, especiallyin relation to delays and capacity at bus stops. First, the principles of bus stop operations arepresented. Issues like the stages of bus stop operations, the classification of times spent at busstops, causes of delays, and the interaction between bus flow and stop delays are analysed.This leads to the necessity of microscopic simulation to study stops operations. Then, anillustration of the sort of understanding that can be achieved with a simulation modem isshown. Simulation experiments regarding arrival patterns of buses and passengers, boardingtimes, difficulties for buses to leave the stop, and vehicle capacity are presented. Resultsindicate that it is important not to underestimate the real situation found at bus stops, asdesigning for ideal conditions will be insufficient if the reality is different.

Nick Tyler

Papers

Effect of door width, platform height and fare collection on bus dwell time. A laboratory study

Object localisation deficits in posterior cortical atrophy and typical alzheimer’s disease: tracking position, movement and fixation patterns within a simulated real-world setting

Transport and Wellbeing

Evaluation of Changes to Bus Stop Design to Benefit Elderly and Disabled People

Study of passenger-bus-traffic interactions on bus stop operations