Nicola Specchia

TL;DR: It is demonstrated for the first time the presence of IL-6-R in the chondrocytes of herniated tissue, which indicates nerve root irritation induced by factors produced by the intervertebral disc may play a crucial role in the pathophysiology of sciatic pain production.

TL;DR: The severity index (SI) is described as a simple method that can be used in the identification of low-dysplastic developmental spondylolisthesis from HDDS allowing earlier surgical stabilization to prevent slip progression and to provide guidelines for using the unstable zone for the inclusion of L4 in stabilization.

TL;DR: The preservation of the anterior C1 arch can contribute to avoid cranial settling and posterior fusion with its related risk of subaxial instability and the EEA provides the same good exposure but with potentially less complications.

TL;DR: Anterior decompression by a minimally invasive EEA could represent an innovative option for the treatment of irreducible ventral CVJ lesions in elderly patients with rheumatoid arthritis, preserving the anterior C1 arch continuity and avoiding a posterior fixation procedure.

TL;DR: The results demonstrate that OP-1 combined with locally obtained autograft is a safe and effective alternative for iliac crest autografted in instrumented single-level posterolateral fusions of the lumbar spine.