N
Nicolaas I. Bohnen
Researcher at University of Michigan
Publications - 225
Citations - 11788
Nicolaas I. Bohnen is an academic researcher from University of Michigan. The author has contributed to research in topics: Parkinson's disease & Cholinergic. The author has an hindex of 57, co-authored 199 publications receiving 9999 citations. Previous affiliations of Nicolaas I. Bohnen include United States Department of Veterans Affairs & Veterans Health Administration.
Papers
More filters
Journal ArticleDOI
Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study.
Nicolaas I. Bohnen,Daniel I. Kaufer,Larry S. Ivanco,Brian J. Lopresti,Robert A. Koeppe,James G. Davis,Chester A. Mathis,Robert Y. Moore,Steven T. DeKosky +8 more
TL;DR: In this article, the authors used positron emission tomography (PET) to determine in vivo cortical acetylcholinesterase (AChE) activity in healthy control subjects and in patients with mild AD, PDem, and Parkinson disease without dementia.
Journal ArticleDOI
Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association.
Keith A. Johnson,Satoshi Minoshima,Nicolaas I. Bohnen,Kevin J. Donohoe,Norman L. Foster,Peter Herscovitch,Jason Karlawish,Christopher C. Rowe,Maria C. Carrillo,Dean M. Hartley,Saima Hedrick,Virginia Pappas,William Thies +12 more
TL;DR: A set of specific appropriate use criteria (AUC) were agreed on that define the types of patients and clinical circumstances in which amyloid PET could be used, and both appropriate and inappropriate uses were considered and formulated, and are reported and discussed here.
Journal ArticleDOI
The Cholinergic System and Parkinson Disease
TL;DR: Early cholinergic denervation in PD without dementia appears to be heterogeneous and may make specific contributions to the PD clinical phenotype, apart from well-known cognitive and behavioral deficits, central, in particular limbic, cholinerg denervation may be associated with progressive deficits of odor identification in PD.
Cortical Cholinergic Function Is More Severely Affected in Parkinsonian Dementia Than in Alzheimer Disease
Nicolaas I. Bohnen,Daniel I. Kaufer,Larry S. Ivanco,Brian J. Lopresti,Robert A. Koeppe,James G. Davis,Chester A. Mathis,Robert Y. Moore,Steven T. DeKosky +8 more
TL;DR: Reduced cortical AChE activity is more characteristic of patients with PDem than of Patients with mild AD, and this work has shown that cholinergic forebrain neuronal losses in parkinsonian dementia are equal to or greater than those in Alzheimer disease.
Journal ArticleDOI
History of falls in Parkinson disease is associated with reduced cholinergic activity
Nicolaas I. Bohnen,Martijn L.T.M. Müller,Robert A. Koeppe,Stephanie A. Studenski,Michael Kilbourn,Kirk A. Frey,Kirk A. Frey,Roger L. Albin +7 more
TL;DR: Unlike nigrostriatal dopaminergic denervation, cholinergic hypofunction is associated with fall status in Parkinson disease (PD), consistent with other data indicating that PPN degeneration is a major factor leading to impaired postural control and gait dysfunction in PD.