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Nicole D. Powell
Researcher at Ohio State University
Publications - 33
Citations - 3370
Nicole D. Powell is an academic researcher from Ohio State University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Immune system. The author has an hindex of 23, co-authored 33 publications receiving 2876 citations. Previous affiliations of Nicole D. Powell include The Ohio State University Wexner Medical Center.
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Journal ArticleDOI
β-Adrenergic Receptor Antagonism Prevents Anxiety-like Behavior and Microglial Reactivity Induced by Repeated Social Defeat
Eric S. Wohleb,Mark L. Hanke,Angela W. Corona,Nicole D. Powell,LaTonia Stiner,Michael T. Bailey,Randy J. Nelson,Jonathan P. Godbout,John F. Sheridan +8 more
TL;DR: It is shown that repeated social defeat in mice increased c-Fos staining in brain regions associated with fear and threat appraisal and promoted anxiety-like behavior in a β-adrenergic receptor-dependent manner.
Journal ArticleDOI
Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
Nicole D. Powell,Erica K. Sloan,Michael T. Bailey,Jesusa M.G. Arevalo,Gregory E. Miller,Edith Chen,Michael S. Kobor,Brenda F. Reader,John F. Sheridan,Steven W. Cole,Steven W. Cole +10 more
TL;DR: The results suggest that sympathetic nervous system-induced up-regulation of myelopoiesis mediates the proinflammatory component of the leukocyte CTRA dynamic and may contribute to the increased risk of inflammation-related disease associated with adverse social conditions.
Journal ArticleDOI
Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.
TL;DR: It is shown that RSD-induced anxiety-like behavior corresponded with an exposure-dependent increase in circulating monocytes and brain macrophages and monocyte recruitment to the brain in response to social stress represents a novel cellular mechanism that contributes to the development of anxiety.
Journal ArticleDOI
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.
Eric S. Wohleb,Ashley M. Fenn,Ann M. Pacenta,Nicole D. Powell,John F. Sheridan,Jonathan P. Godbout +5 more
TL;DR: Findings demonstrate that repeated social defeat enhanced the neuroinflammatory response and caused prolonged sickness following innate immune challenge.
Journal ArticleDOI
Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.
Eric S. Wohleb,Daniel B. McKim,D.T. Shea,Nicole D. Powell,Andrew J. Tarr,John F. Sheridan,Jonathan P. Godbout +6 more
TL;DR: The findings show that neuroinflammatory mechanisms promote mood disturbances following stress-sensitization and outline novel neuroimmune interactions that underlie recurring anxiety disorders such as posttraumatic stress disorder.