N
Niesko Pras
Researcher at University of Groningen
Publications - 79
Citations - 3476
Niesko Pras is an academic researcher from University of Groningen. The author has contributed to research in topics: Artemisia annua & Linum flavum. The author has an hindex of 38, co-authored 79 publications receiving 3341 citations. Previous affiliations of Niesko Pras include University of Düsseldorf.
Papers
More filters
Journal ArticleDOI
Cytotoxicity of Artemisinin-Related Endoperoxides to Ehrlich Ascites Tumor Cells
Herman J. Woerdenbag,Tamara A. Moskal,Niesko Pras,Theo M. Malingré,Farouk S. El-Feraly,Harm H. Kampinga,Antonius W.T. Konings +6 more
TL;DR: A series of artemisinin-related endoperoxides was tested for cytotoxicity to Ehrlich ascites tumor (EAT) cells using the microculture tetrazolium (MTT) assay.
Journal ArticleDOI
Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: Proof for the existence of chemotypes
TL;DR: The time course of the levels of artemisinin, its biosynthetic precursors and the biosynthetically related sesquiterpenes was monitored during a vegetation period of Artemisia annua plants of different geographical origin to suggest the presence of high levels of dihydroartemisinic acid may be an adaptation to stress conditions.
Journal ArticleDOI
Isolation and Identification of Dihydroartemisinic Acid from Artemisia annua and Its Possible Role in the Biosynthesis of Artemisinin
TL;DR: The results suggest that the conversion of 2 into 4 in the living plant might be a nonenzymatic conversion.
Journal ArticleDOI
Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L.
TL;DR: From aseptically grown Artemisia annua plantlets, shoot cultures were initiated and attempts were made to improve the artemisinin production by varying the medium composition through addition of gibberellic acid or casein hydroly-state.
Journal ArticleDOI
Stereochemistry-Dependent Cytotoxicity of Some Artemisinin Derivatives
AC Beekman,A.R.W. Barentsen,Herman J. Woerdenbag,W van Uden,Niesko Pras,F.S El Feraly,A.M Galal,Håkan Wikström +7 more
TL;DR: The results suggested that the endoperoxide bridge was not crucial for cytotoxicity to the tumor cells, but contributed to the cytotoxic effect apparently exerted by the ether linkage of the dimers.