Ningyu Tian

TL;DR: This study indicates that the acidosis–CYP24A1–vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignantglioma in the future.

TL;DR: Gliomas account for approximately 80% of primary malignant tumors in the central nervous system and despite aggressive therapy, the prognosis of patients remains extremely poor, and the old antibiotic, clofoctol, was identified as the most effective compound, showing reduction of colony-formation and induction of apoptosis of GSCs.

TL;DR: The results demonstrate that NSPc1 promotes cancer stem cell self-renewal by repressing the synthesis of ATRA via targeting RDH16 and may provide novel targets for glioma treatment in the future.

TL;DR: It is shown that glioma-associated human endothelial cells (GhECs), a main component of the perivascular niche, release extracellular vesicles (EVs) that increase GSC proliferation and tumour-sphere formation and enhances the aggressiveness of glioblastoma by specifically maintaining GSCs.

TL;DR: A link is established between UNR and RPL9 protein, which will provide new ideas for the further study of glioma and establish a link between the 3' untranslated region (UTR) of PTEN and R PL9 mRNAs.