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Noah J. Pyles
Researcher at University of Pittsburgh
Publications - 2
Citations - 328
Noah J. Pyles is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Neurodegeneration & Amyotrophic lateral sclerosis. The author has an hindex of 2, co-authored 2 publications receiving 208 citations.
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Journal ArticleDOI
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Jacob R. Mann,Amanda M. Gleixner,Jocelyn C. Mauna,Edward Gomes,Michael R. DeChellis-Marks,Patrick G. Needham,Katie E. Copley,Bryan Hurtle,Bede Portz,Noah J. Pyles,Lin Guo,Christopher B. Calder,Zachary P. Wills,Udai Bhan Pandey,Julia Kofler,Jeffrey L. Brodsky,Amantha Thathiah,James Shorter,Christopher J. Donnelly +18 more
TL;DR: The formation of pathologically relevant inclusions is driven by aberrant interactions between low-complexity domains of TDP-43 that are antagonized by RNA binding, and it is shown that aberrant phase transitions of cytoplasmic TTP are neurotoxic and that treatment with oligonucleotides composed of T DP-43 target sequences prevent inclusions and rescue neurotoxicity.
Journal ArticleDOI
Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo.
Charlton Otte,Tyler R. Fortuna,Jacob R. Mann,Amanda M. Gleixner,Nandini Ramesh,Noah J. Pyles,Udai Bhan Pandey,Christopher J. Donnelly +7 more
TL;DR: A model for the optogenetic induction of TDP-43 aggregation in Drosophila that recapitulates key biochemical features seen in patient pathology, most notably light-inducible persistent insoluble species and progressive motor dysfunction is presented.