N
Nobuhiko Okabe
Researcher at National Institutes of Health
Publications - 228
Citations - 6243
Nobuhiko Okabe is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Outbreak & Vaccination. The author has an hindex of 36, co-authored 227 publications receiving 5697 citations.
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Journal ArticleDOI
Genetic Analysis of Human Norovirus Strains in Japan in 2016-2017.
Koo Nagasawa,Yuki Matsushima,Takumi Motoya,Fuminori Mizukoshi,Yo Ueki,Naomi Sakon,Koichi Murakami,Tomomi Shimizu,Nobuhiko Okabe,Noriko Nagata,Komei Shirabe,Hiroto Shinomiya,Wataru Suzuki,Makoto Kuroda,Tsuyoshi Sekizuka,Yoshiyuki Suzuki,Akihide Ryo,Kiyotaka Fujita,Kazunori Oishi,Kazuhiko Katayama,Hirokazu Kimura,Hirokazu Kimura +21 more
TL;DR: The time-scale phylogeny suggested that the common ancestors of the 2016 strains VP1 gene and RdRp region diverged in 2006 and 1999, respectively, and that the 2016 strain was the progeny of a pre-2016 GII.2.2 strains.
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Encephalitis and Encephalopathy Associated with an Influenza Epidemic in Japan
Tsuneo Morishima,Takehiro Togashi,Shyumpei Yokota,Yoshinobu Okuno,Chiaki Miyazaki,Masato Tashiro,Nobuhiko Okabe +6 more
TL;DR: F influenza-associated encephalitis/encephalopathy progressed rapidly and was associated with poor outcomes, and thrombocytopenia and severely elevated transaminase levels were factors associated with a poor prognosis.
Journal ArticleDOI
Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011.
Tsuguto Fujimoto,Setsuko Iizuka,Miki Enomoto,Katsuhiko Abe,Kazuyo Yamashita,Nozomu Hanaoka,Nobuhiko Okabe,Hiromu Yoshida,Yoshinori Yasui,Masaaki Kobayashi,Yoshiki Fujii,Hiroko Tanaka,Miwako Yamamoto,Hiroyuki Shimizu +13 more
TL;DR: Typical clinical signs and symptoms of HFMD cases caused by CVA6 were fever, mild vesicles in oral mucosa, and skin blisters on hands, arms, feet, legs, buttocks, and nail matrixes (Figure).
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Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region.
Yuki Matsushima,M Ishikawa,T Shimizu,Ayako Komane,Shizuko Kasuo,Michiyo Shinohara,Koo Nagasawa,Hirokazu Kimura,Akihide Ryo,Nobuhiko Okabe,Kei Haga,Yen Hai Doan,Kazuhiko Katayama,H Shimizu +13 more
TL;DR: A novel GII.P17-GII.17 variant norov virus emerged as a major cause of norovirus outbreaks from December 2014 to March 2015 in Japan and has a newly identified GII-P17 type RNA-dependent RNA polymerase, while the capsid sequence displays amino acid substitutions around histo-blood group antigen (HBGA) binding sites.
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Enterovirus 71 from Fatal and Nonfatal Cases of Hand, Foot and Mouth Disease Epidemics in Malaysia, Japan and Taiwan in 1997-1998
Hiroyuki Shimizu,Andi Utama,Kumiko Yoshii,Hiromu Yoshida,Tetsuo Yoneyama,Sinniah M,Yusof Ma,Okuno Y,Nobuhiko Okabe,Shih,Chen Hy,Wang Gr,Chuan-Liang Kao,Chang Ks,Tatsuo Miyamura,Akio Hagiwara +15 more
TL;DR: The nucleotide sequences of each EV71 isolate were determined and compared by phylogenetical analysis, and the severity of the HFMD did not link directly to certain genotypes of EV71, including genotype A-2.