Showing papers by "Nobuo Shimma published in 1984"
TL;DR: A novel antibiotic, penitricin showing anti-Gram-negative activity, has been isolated from the culture filtrate of Penicillium aculeatum and its structure was determined as hydroxymethylcyclopropenone by chemical synthesis from propargyl alcohol.
Abstract: A novel antibiotic, penitricin showing anti-Gram-negative activity, has been isolated from the culture filtrate of Penicillium aculeatum. Chemical and physico-chemical studies determined the structure of penitricin as hydroxymethylcyclopropenone (1), which was confirmed by chemical synthesis from propargyl alcohol. Biological activity of penitricin and several cyclopropenones as well as two metabolites, penitricins B and C was compared.
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