The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.

Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom

The invention relates to the film products and methods of their preparation that 5 demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% 10 variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. lc:: -16 10' FIG. 4 18 0

Polyethylene oxide-based films and drug delivery systems made therefrom

A modular insert for curb-inlet storm drains creates a composite collection system for trash and for oil or other hydrocarbons and related chemicals. A hopper contains a multitude of irregular, macroscopic fragments of a hydrophobic, compliant, oil-absorbent, copolymer material having high surface area. Preferably, the material is formed with a binder in a novel extrusion process. The fragments absorb and retain permanently a high quantity of oil and other chemicals passing through the hopper, while permitting a high water flow-through rate. The fragments are held in place by a removable bottom plate, which allows replacement of the filtering fragments, and an internal basket. Trash and debris are collected in the internal basket. The hopper is configured to be suspended in a storm drain adjacent to a curb inlet on a bracket and can be installed or serviced through a conventional manhole entry. The hopper has a side cutout that permit lateral overflow from one of the modular units to an adjacent one.

Curb-inlet storm drain systems for filtering trash and hydrocarbons

A process is provided for the selective removal of basic materials from plant products, in particular, for removing nicotine from tobacco without materially affecting the content of the other components of the tobacco. Tobacco is traversed with a solvent at high pressure and in a physical state which is either a liquid at a pressure of from about 500-300 atmospheres or a supercritical fluid wherein nicotine and the other components dissolve in the solvent. As the single means of removing substances from the solvent, the solvent is then passed through an acid-containing trap where the solvent is essentially freed of nicotine. The solvent, depleted of nicotine and enriched in the other components, is then recycled to the tobacco to reextract nicotine. In addition, the tobacco may be pretreated with a chemical base which does not substantially react with the tobacco components under ambient conditions and which are not necessarily affected by the process conditions but are nonetheless effective in increasing the amount of nicotine which can be extracted by the process of this invention. Pretreatment of the tobacco with a chemical base neutralizes nicotine salts and permits the extraction process to be carried out under milder conditions.

Process for removal of basic materials

The present invention relates to rapid dissolve thin film drug delivery compositions for the oral administration of active components. The active components are provided as taste-masked or controlled-release coated particles uniformly distributed throughout the film composition. The compositions may be formed by wet casting methods, where the film is cast and controllably dried, or alternatively by an extrusion method.

Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

Stable cellulosic products containing releasable flavorant are described. These products are produced by impregnating a dry cellulosic substrate with an essentially anhydrous ammonia solution of a volatile flavorant and then subjecting the impregnated substrate to conditions of temperature and pressure sufficient to effect evaporation of essentially all of the impregnated solvent.

Process for incorporating flavorant into cellulosic substrates and products produced thereby

Microporous styrene polymers are provided having randomly interconnected open network of irregularly shaped pores whose walls consist of cohered spherical particles of the polymer. These microporous styrene polymers are produced by mixing styrene polymer latex with a water-soluble ether, casting, molding, or impregnating the resulting mixture into a fibrous material, heating same to a temperature of from about 80° C to about 120° C and removing the ether.

Microporous styrene polymers and method of making same

A catalyst is provided which is remarkably effective for catalyzing the oxidation of carbon monoxide to carbon dioxide at ambient conditions. This catalyst is prepared by contacting high surface area alumina with a solution of a cobalt compound (e.g., cobalt nitrate), adsorbing the cobalt compound on the alumina, removing the solvent, and thereafter heating the cobalt-treated alumina at a temperature of 400 DEG C to 1,300 DEG C in an oxygen-providing environment.

Catalyst and process for making same

This disclosure relates to a novel process and to a novel product produced thereby. The product comprises a vinyl chloride polymer having an improved microporous structure and is made by a process which involves dispersing a vinyl chloride polymer latex, i.e., an aqueous suspension of a vinyl chloride polymer, in an organic liquid which is a non-solvent for the polymer, preferably removing most of the water, and heating the resulting dispersion to sinter the vinyl chloride polymer particles to form a microreticulated microporous structure. The vinyl chloride polymer latex may, for example, be a colloidal suspension of polyvinyl chloride particles in water. Such a latex may be obtained commercially or may be prepared by conventional methods. The non-solvent organic liquids should be water-miscible and should have a boiling point above 130* C. and exhibit substantially no solvating or swelling effect on the vinyl chloride polymer. The improved microporous structure of this invention is particularly useful as a filter material. The process of the invention is especially suited for the formation of shaped porous articles which are useful as filters.

Microporous structure and method of making the same

Novel compositions are prepared by impregnating activated alumina with sodium permanganate and a basic sodium compound. When used as a granular filter material in combination with a tobacco product as in a smoking article comprising a cigarette in combination with the filter materials, nitrogen oxides can be significantly reduced in the smoke obtained from the tobacco product after the filter material is stored for long periods of time in the presence of the volatile components of the tobacco product and/or moisture. Activated carbon may also be combined with the composition.

Norman B Rainer

Papers

Process for incorporating flavorant into cellulosic substrates and products produced thereby

Microporous styrene polymers and method of making same

Catalyst and process for making same

Microporous structure and method of making the same

Smoking product and process